Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes

Zastulka, Ana; Clichici, Simona; Tomoaia-Cotişel, Maria; Mocanu, Aurora; Roman, Cecilia; Olteanu, Cristian-Doru; Culic, Bogdan; Mocan, Teodora

doi:10.3390/ma16031303

Cited by 22 publications

(10 citation statements)

References 205 publications

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“…This seems to be in agreement with reports by Hou et al [ 3 ] and Marques Loureiro et al [ 5 ], who observed that chronic intake of an unbalanced high-fat diet can contribute to disorders in bone modelling and remodelling by increasing the risk of deficiencies of important nutrients involved in bone metabolism, such as calcium, phosphorus, and vitamin D 3 . Ca and P are essential tohydroxyapatite synthesis andbone mineralization, ensuring adequate bone strength [ 37 ]. Sufficient amounts of calcium and phosphates fornormal mineralizationcan be ensured by the active form ofvitamin D 3 ,regarded as a factor activating osteoclast maturation processes by increasing the expression of RANKL and reducing OPG levels [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet

Cholewińska,

Sołek,

Juśkiewicz

et al. 2024

PLoS ONE

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The aim of the study was to investigate the effect of returning to a balanced diet combined with chromium picolinate (CrPic) or chromium nanoparticles (CrNPs) supplementation at a pharmacologically relevant dose of 0.3 mg/kg body weight on the expression level of selected genes and bone turnover markers in the blood and bones of rats fed an obese diet. The results of the study showed that chronic intake of a high-fat obesogenic diet negatively affects bone turnover by impairing processes of both synthesis and degradation of bones. The switch to a healthy diet proved insufficient to regulate bone metabolism disorders induced by an obesogenic diet, even when it was supplemented with chromium, irrespective of its form. Supplementation with CrPic with no change in diet stimulated bone metabolism only at the molecular level, towards increased osteoclastogenesis (bone resorption). In contrast, CrNPs added to the high-fat diet effectively regulated bone turnover by increasing both osteoblastogenesis and osteoclastogenesis, with these changes directed more towards bone formation. The results of the study suggest that unfavourable changes in bone metabolism induced by chronic intake of a high-fat diet can be mitigated by supplementation with CrNPs, whereas a change in eating habits fails to achieve a similar effect.

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Section: Discussionmentioning

confidence: 99%

Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet

Cholewińska,

Sołek,

Juśkiewicz

et al. 2024

PLoS ONE

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“…This potential advancement could lead to toothpastes tailored to various levels of enamel damage and sensitivity. Another approach could be to develop hydroxyapatite nanoparticles that accurately transport active compounds, such as antimicrobial or anti-inflammatory molecules [29]. These nanoparticles might be engineered to gradually release beneficial bio-compounds over time.…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxyapatite is used as such in toothpastes [25][26][27] and bone regeneration [28,29], or as substituted in its lattice with various physiological elements to enhance its bioactivity, like Zn [30], Zn-carbonate [31], Sr [32,33], Zn and Sr [34], Cu and Zn [35], Zn and fluoride [36], fluorine [37], Ag and fluoride [38], Mg and Sr [39], Mg [40], Mg and Zn [41], Mg and Si [42], Ag [43], and Si [44]. These components play various roles; for some, the particular role they play in the substituted HAP is known; for others, it is only assumed.…”

Section: Introductionmentioning

confidence: 99%

Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Florea,

Pop,

Benea

et al. 2023

Biomimetics

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This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experimental design. Tooth enamel surfaces were investigated using atomic force microscope (AFM) images and surface roughness (Ra) determined before and after treatment. The surface roughness of enamel slices was statistically analyzed by one-way ANOVA and Bonferroni’s multiple comparison test. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data revealed the HAP structure with crystal sizes between 28 and 33 nm and crystallinity between 29 and 37%. The average size of HAP particles was found to be between 30 and 40 nm. The Ra values indicated that P3 (HAP-Mg-Zn-Sr-Si) toothpaste was the most effective after 10 days of treatment, leading to the lowest mean roughness. The P3 and P2 (HAP) toothpastes were found to be effective in promoting remineralization. Specifically, their effectiveness can be ranked as follows: P3 = P2 > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn), considering both the chemical composition and the size of their constitutive nanoparticles. The proposed toothpastes might be used successfully to treat early tooth decay.

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“…Recent trends towards strontium substituting calcium in hydroxyapatite have resulted in increased crystallinity and bioactivity [17]. Strontium exhibits osteoinduction and high solubility.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Remineralisation Potential of an Indigenously Developed Dentifrice – An In Vitro Study

Rao Setvaji,

Kumar Subramanian

2024

TIJPH

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White spot lesions are a regrettable but frequent side effect of orthodontic treatment that can be avoided by using dentifrices that encourage enamel remineralization. To evaluate the remineralising efficacy of an indigenously developed dentifrice containing green synthesised strontium fluorapatite nanoparticles (SrFAp NPs). SrFAp NPs were green synthesised using plant extracts of Equisetum arvense and Laminariales along with fluorine and hydroxyapatite precursors. Characterisation and cytotoxicity evaluation of the SrFAp NPs was done. Remineralising efficacy was evaluated on 30 extracted non carious teeth separated into 1 control group and 5 test groups of 5 teeth each. All samples underwent demineralisation and remineralisation. The test groups were exposed to the corresponding concentration of SrFAp NPs dentifrice. The pre and post treatment Vickers hardness test and Energy dispersive x-ray analysis were performed. Statistical analysis done using SPSS software. Characterisation and cytotoxicity tests revealed successful formation of SrFAp NPs with good cell viability. Increase in enamel hardness values seen in all test groups post treatment. Highly significant difference in enamel hardness values seen in 0.1%, 0.8% and 1% SrFAp dentifrices. EDAX analysis shows strontium uptake in all the test groups. 0.1 Wt%, 0.2 Wt%, 0.1 Wt%, 0.5 Wt%, 0.2 Wt% of Sr uptake seen in 0.1%, 0.2%, 0.4%, 0.8% and 1% SrFAp dentifrices respectively. SrFAp NPs containing dentifrices have successfully remineralised enamel leading to increased enamel hardness. EDAX shows successful uptake of strontium of highest 0.5 Wt% seen with 0.8% SrFAp NP dentifrice.

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Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes

Cited by 22 publications

References 205 publications

Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet

Chromium nanoparticles improve bone turnover regulation in rats fed a high-fat, low-fibre diet

Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Evaluation of Remineralisation Potential of an Indigenously Developed Dentifrice – An In Vitro Study

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