Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Florea, Alexandra-Diana; Pop, Lucian Cristian; Benea, Horea-Rares-Ciprian; Tomoaia, Gheorghe; Racz, Csaba-Pal; Mocanu, Aurora; Dobrota, Cristina-Teodora; Balint, Reka; Soritau, Olga; Tomoaia-Cotisel, Maria

doi:10.3390/biomimetics8060450

Cited by 8 publications

(16 citation statements)

References 70 publications

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“…A number of studies have shown that Coca-Cola ® decreased the salivary pH immediately after consumption [35][36][37]39,40], but generally it did not produce a decrease in salivary pH below 5.5 [35][36][37]. The pH value of 5.5 was found to be critical for enamel dissolution and caries development in vitro [56,61]; at the same time, in vivo this value varies over a wide range depending on the individual characteristics of the enamel and the content of mineral ions in plaque fluid and saliva [73][74][75]. In relation to erosion, critical pH is reversely proportional to the calcium and phosphate concentrations not only in the saliva and plaque fluid, but also in the foods and drinks.…”

Section: Discussionmentioning

confidence: 99%

“…BF active ingredients include Zn-hydroxyapatite and a probiotic. Remineralizing properties of hydroxyapatite are well documented [53][54][55][56]94,95]. Biomimetic (hydroxyapatite-containing) oral care products replicate the natural structure of teeth and can promote the remineralization of hard tooth tissues [53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

“…Remineralizing properties of hydroxyapatite are well documented [53][54][55][56]94,95]. Biomimetic (hydroxyapatite-containing) oral care products replicate the natural structure of teeth and can promote the remineralization of hard tooth tissues [53][54][55][56]. Particularly hydroxyapatite doped with Zn ions has been found to be an effective agent in mineralizing hard tooth tissues [94][95][96].…”

Section: Discussionmentioning

confidence: 99%

“…Another approach is to use oral care products immediately after acidic exposure. Regarding anti-erosive and remineralizing potential, the most promising results have been reported for fluoride-and hydroxyapatite-containing products [20,[50][51][52][53][54][55][56]. Alkaline oral care products may also be of interest due to their ability to increase salivary pH [57][58][59].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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Soft drinks may have a deleterious effect on dental health due to a high titratable acidity and a low pH that could be sufficient to induce tooth demineralization. The use of oral care products immediately after acidic challenge may diminish the erosive potential of soft drinks. We assessed the effect of oral care foams and a spray on salivary pH changes after exposure to Coca-Cola® in young adults. Thirty-three consenting eligible patients were recruited in this double-blind, randomized, crossover study performed in six visits. Baseline examination included unstimulated salivary flow rate, stimulated salivary buffer capacity, and the simplified oral hygiene index (OHI-S) assessment. Salivary pH and time for pH recovery were registered after exposure to Coca-Cola® alone or that followed by the application of each of the studied products (an oral foam containing hydroxyapatite and probiotics, an oral foam containing amino fluoride, an alkaline oral spray, and tap water). Thirty-two patients completed the entire study protocol and were included in the final analysis. The mean minimum salivary pH and the mean oral clearance rate after rinsing with Coca-Cola® were 6.3 and 27 min, respectively. Further rinsing with any one of the tested solutions, including tap water, resulted in a significant improvement in these parameters. When the pH curves were plotted, the oral care products demonstrated a lower area under the curve that differed significantly from the area under the curve for Coca-Cola®; tap water did not differ significantly from Coca-Cola® and oral care products. Minimum salivary pH correlated positively with salivary buffer capacity and salivation rate, while salivary clearance correlated with OHI-S plaque scores. In conclusion, the effect of oral care foams and a spray on minimum salivary pH and salivary clearance after exposure to Coca-Cola® did not differ significantly among the tested products and tap water. Trial registration NCT06148662. Funding: none.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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“…atomic force microscopy (AFM) is also a suitable technique for evidencing changes in enamel topography because it can provide more quantitative results on surface roughness. Several articles have been published that use the AFM technology to track erosion and demineralization changes in enamel [47][48][49][50][51][52][53][54][55].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dobrota,

Florea,

Racz

et al. 2024

Materials

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To address tooth enamel demineralization resulting from factors such as acid erosion, abrasion, and chronic illness treatments, it is important to develop effective daily dental care products promoting enamel preservation and surface remineralization. This study focused on formulating four toothpastes, each containing calcined synthetic hydroxyapatite (HAP) in distinct compositions, each at 4%, along with 1.3% birch extract. Substitution elements were introduced within the HAP structure to enhance enamel remineralization. The efficacy of each toothpaste formulation was evaluated for repairing enamel and for establishing the dynamic of the remineralization. This was performed by using an in vitro assessment of artificially demineralized enamel slices. The structural HAP features explored by XRD and enamel surface quality by AFM revealed notable restorative properties of these toothpastes. Topographic images and the self-assembly of HAP nanoparticles into thin films on enamel surfaces showcased the formulations’ effectiveness. Surface roughness was evaluated through statistical analysis using one-way ANOVA followed by post-test Bonferroni’s multiple comparison test with a p value < 0.05 significance setting. Remarkably, enamel nanostructure normalization was observed within a short 10-day period of toothpaste treatment. Optimal remineralization for all toothpastes was reached after about 30 days of treatment. These toothpastes containing birch extract also have a dual function of mineralizing enamel while simultaneously promoting enamel health and restoration.

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The Evolution of Robin Sequence Treatment based on the Biomimetic Interdisciplinary Approach: A Historical Review

Čverha,

Varga,

Trenčanská

et al. 2023

Preprint

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Robin sequence is a congenital anomaly characterized by a triad of features that include micrognathia, glossoptosis, and airway obstruction. This comprehensive historical review maps the evolution of approaches and appliances for its treatment from the past until current modern possibilities of interdisciplinary combination of modern engineering, medicine, materials, and computer science combined approach with emphasis to design appliances inspired by nature - individual human anatomy. Current biomimetic designs are clinically applied resulting in appliances that are more efficient, comfortable, sustainable, and safer than legacy traditional designs. Review maps the treatment modalities that have been used for patients with Robin sequence over the years. Early management of Robin sequence focused primarily on airway maintenance and feeding support, while current management strategies involve both nonsurgical and surgical interventions and biomimetic biocompatible personalized appliances. The goal of this paper was to provide a review of the evolution of management strategies for patients with Robin sequence that led to the current interdisciplinary biomimetic approaches impacting the future of Robin Sequence treatment with biomimetics at the forefront.

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Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Cited by 8 publications

References 70 publications

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

The Evolution of Robin Sequence Treatment based on the Biomimetic Interdisciplinary Approach: A Historical Review

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