Recent Studies on Natural Products as Anticancer Agents

Ravelo, Ángel G.; Estévez‐Braun, Ana; Chávez, Haydee; Perez-Sacau, Elisa; Mesa-Siverio, Dulce

doi:10.2174/1568026043451500

Cited by 140 publications

(90 citation statements)

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“…Tingenone (5) is a pentacyclic triterpene with known cytotoxic properties. 32 In the present work, this terpene showed higher toxicity when compared to the other samples of M. imbricata tested. This terpene is the main constituent found in the extracts HES (40%) and HEE (9.4%).…”

Section: Evaluation Of Cytotoxic Potentialsupporting

confidence: 43%

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Rodrigues¹,

Duarte²,

Silva³

et al. 2012

Quím. Nova

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Recebido em 3/10/11; aceito em 26/2/12; publicado na web em 2/7/12The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1 H and 13 C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

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Section: Evaluation Of Cytotoxic Potentialsupporting

confidence: 43%

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Rodrigues¹,

Duarte²,

Silva³

et al. 2012

Quím. Nova

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“…1,4-Naphthoquinone is an important example of quinone family and is used as a raw material in pharmaceutical industries. 1,4-Naphthoquinone and its derivatives exhibited several interesting and different biological responses including antibacterial, 3 antifungal, 4,5 anti-inflammatory, antiplatelet, antiallergic, 6 antithrombotic, 7 antiviral, 8 anticancer, [9][10][11] apoptosis, 12 lipoxygenase, 13,14 radical scavenging 15 and anti-ringworm 16 activities. Recently, 1,4-Naphthoquinone derivatives were proved to be human DNA topoisomerase I and II inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines

Kishore

Binneman

Mahapatra

et al. 2014

Bioorganic & Medicinal Chemistry

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In an effort to establish new candidates with enhanced anticancer activity of 5-hydroxy-7-methyl-1,4-naphthoquinone scaffold (7-methyljuglone) previously isolated from the root extract of Euclea natalensis, a series of 7-methyljuglone derivatives have been synthesized and assessed for cytotoxicity on selected human cancer lines. These compounds were screened in vitro for anticancer activity on MCF-7, HeLa, SNO and DU145 human cancer cell lines by MTT assay. Most of them exhibited significant toxicity on cancer cell lines with lower IC 50 values. The most potent derivative (19) exhibited the toxicity on HeLa and DU145 cell lines with IC 50 value of 5.3 and 6.8 µM followed by compound (5) with IC 50 value of 10.1 and 9.3 µM, respectively. Structureactivity relationship reveals that the fluoro substituents at position C-8 while hydroxyl substituents at C-2 and C-5 positions played an important role in toxicity.

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“…1 There is resurging interest in the possible use of natural products for treatment of malignant disease 2 and their potential for further chemical modification.…”

Section: Introductionmentioning

confidence: 99%

Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro

et al. 2007

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We investigated if deguelin, a naturally occurring rotenoid, was able to inhibit nuclear factor kappa B (NF-jB)-binding protein (IjBa) expression and to induce apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells in vitro. Deguelin-induced cell death in the majority of B-CLL cells and was found to be more toxic toward B-CLL cells than to the normal mononuclear or B-cells, suggesting selectivity towards the malignant cells. Deguelin was found to reduce IjBa protein expression, and thus interacts with the NFjB pathway. The induced apoptosis was characterized by processing of caspase-9 and -3 and poly-(ADP)-ribose-polymerase cleavage. Exposure of B-CLL cells to deguelin resulted in Bcl2-associated protein (Bax) conformational changes and downregulation of the key survival protein myeloid cell leukemia sequence 1 (Mcl-1), which is associated with response to treatment in B-CLL patients. Deguelin retained its ability to induce apoptosis in B-CLL cells in the presence of interleukin-4, a pro-survival cytokine in B-CLL, and when cultured with 50% human serum. These data indicate that deguelin is able to induce apoptosis in B-CLL cells in the presence of pro-survival signals and thus merits further investigation for clinical application either as a single agent or in combination with other anticancer agents.

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Recent Studies on Natural Products as Anticancer Agents

Cited by 140 publications

References 0 publications

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Cytotoxicity of synthesized 1,4-naphthoquinone analogues on selected human cancer cell lines

Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro

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