materials due to the surface-induced clotting and thrombus formation that can cause device failure. [1,2] The proliferation of smooth muscle cells (SMCs) on the surfaces of foreign materials may lead to restenosis upon implantation of cardiovascular devices such as stents. [3] The intimal hyperplasia and thrombosis are the main reasons that lead to low retrievable rate of inferior vena cava filters (IVCs). [4] It is a major challenge to create a safe bloodcontacting surface balancing cytocompatibility and antithrombogenic effects. [2,[5][6][7][8][9][10] In addition, the bacterial infection of cardiovascular devices such as catheters and artificial blood vessels must be avoided, as it may also cause implant failures, while being life-threatening in extreme cases. [11] Shellac (also known as lac) is a natural resin that can potentially be used as a bioactive material to modify the surfaces of blood-contacting devices. Shellac is secreted by shellac insects that parasitize on branches of certain legumes by sucking the sap. [12] It is composed of polyester and single ester with polyhydroxypolybasic acids such as aleuritic acid, jalaric acid, and laccijalaric acid with the chemical structure depicted in Figure 1a. [13] The hydrophobic (aleuritic acid) and hydrophilic (cyclic terpene acid) components of shellac are linked with each other through ester bonds, providing it with an amphiphilic nature. [13] Shellac