Recent Progress in the Synthesis of Heterocycles based on 1,3-diketones

Talbi, Soumaya; Dib, Mustapha; Bouissane, Latifa; Hafid, Abderrafia; Rabi, Souad; Khouili, Mostafà

doi:10.2174/1570179418666211011141428

Cited by 3 publications

(3 citation statements)

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“…The 1,3-dicarbonyl-fused coumarin derivatives were synthesized through the widely used method of the Pechmann condensation with slight modifications. The compounds were characterized using different spectral techniques [ 14 , 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Coumarin-based compounds find utilization as distinctive antivirals. The current study involved the identification, screening, and designing of novel compounds with improved therapeutic profiles that were created using scaffold morphing and structure-based designing techniques [ 15 ]. Scaffold morphing, a revolutionary medicinal chemistry technique, modifies the scaffold to produce corresponding molecules with a potentially higher therapeutic profile.…”

Section: Introductionmentioning

confidence: 99%

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Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2

Sharma,

Singh,

Sharma

et al. 2024

Molecules

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SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replication cycle could be a potential therapeutic option to counter its viral growth in the human body leading to the severe infectious stage. The Mpro of SARS-CoV-2 is a promising target for therapeutic development as it is crucial for viral transcription and replication. The derivatives of β-diketone and coumarin have already been reported for their antiviral potential and, thus, are considered as a potential scaffold in the current study for the computational design of potential analogs for targeting the viral replication of SARS-CoV-2. In our study, we used novel diketone-hinged coumarin derivatives against the SARS-CoV-2 MPro to develop a broad-spectrum antiviral agent targeting SARS-CoV-2. Through an analysis of pharmacokinetics and docking studies, we identified a list of the top 10 compounds that demonstrated effectiveness in inhibiting the SARS-CoV-2 MPro virus. On the basis of the pharmacokinetics and docking analyses, the top 5 novel coumarin analogs were synthesized and characterized. The thermodynamic stability of compounds KS82 and KS94 was confirmed by their molecular dynamics, and the stability of the simulated system indicated their inhibitory nature. Molecules KS82 and KS94 were further evaluated for their anti-viral potential using Vero E6 cells followed by RT-PCR assay against SARS-CoV-2. The test compound KS82 was the most active with the potential to inhibit SARS-CoV-2 replication in Vero E6 cells. These data indicate that KS82 prevents the attack of the virus and emerges as the primary candidate with promising antiviral properties.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2

Sharma,

Singh,

Sharma

et al. 2024

Molecules

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“…Numerous theories have been put forth about the primary factors in AD: a few contend that cholinergic dysfunction is a significant risk aspect for AD, whereas others contend that changes in the manufacturing and analysing of amyloid-protein are the primary triggering factors. However, there is currently no widely recognised hypothesis for the onset of AD [13,14].…”

Section: Introductionmentioning

confidence: 99%

In Silico Approaches to Developing Novel Glycogen Synthase Kinase 3β (GSK-3β)

Goyal,

Singh,

Thirumal

et al. 2023

Biomedicines

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Alzheimer’s disease (AD) is caused by plaque agglomeration and entanglement in several areas of the neural cells, which leads to apoptosis. The main etiology of AD is senile dementia, which is linked to amyloid-beta (Aβ) deregulation and tau perivascular pathogeny. Hyperphosphorylated tau has a propensity for microtubules, which elevate the instability and tau-protein congregates, leading to accumulation of neurofibrillary tangles (NFTs). Tau hyperphosphorylation is susceptible to GSK-3, which has led to an emerging hypothesis regarding the pathogenesis of AD. Accordingly, attempts have been made to conduct investigations and achieve further advancements on new analogues capable of inhibiting the GSK-3 protein, which are currently in the clinical trials. In this analysis, we have evaluated certain GSK-3 inhibitor variants utilising scaffolding and framework devised techniques with pharmacological characteristics, accompanied by computational screenings (pharmacokinetics and docking). The structure-based designed analogues interacted effectively with the active amino acids of GSK-3β target protein. The in silico pharmacokinetic studies revealed their drug-like properties. The analogues with best interactions and binding scores will be considered in the future to completely demonstrate their potential relevance as viable GSK-3 inhibitors.

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A Review on the Recent Progress of Layered Double Hydroxides (LDHs)-based Catalysts for Heterocyclic Synthesis

Farouki,

Kacem,

Dib

et al. 2024

COCAT

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Over the past decade, heterocyclic compounds and their derivatives have emerged as promising substances with potential pharmacological applications due to their interesting biological properties. The significance of heterocyclic compounds in drug discovery and development is evident from the fact that a majority of drugs in the pharmaceutical market incorporate heterocyclic compounds as active substances or ingredients. Various synthetic methods and advancements have been devised to prepare these heterocyclic compounds using diverse catalysts under mild conditions. Layered double hydroxides (LDHs)-based materials have gained considerable attention across different fields, and their usability can be significantly enhanced via the selection of metal cations, their molar ratios, surface complexation, and intercalation modifications. The synthesis and application of LDH-based materials as catalysts have garnered increasing interest due to their exceptional properties. Moreover, LDH-based materials have found extensive use as heterogeneous catalysts in the synthesis of numerous heterocyclic compounds. This review presents the latest developments in the catalytic application of LDH-based materials as solid heterogeneous catalysts in the synthesis of heterocyclic compounds, covering literature published from 2018 to 2023.

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Recent Progress in the Synthesis of Heterocycles based on 1,3-diketones

Cited by 3 publications

References 104 publications

Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2

Design, Synthesis, and Biological Evaluation of Novel Coumarin Analogs Targeted against SARS-CoV-2

In Silico Approaches to Developing Novel Glycogen Synthase Kinase 3β (GSK-3β)

A Review on the Recent Progress of Layered Double Hydroxides (LDHs)-based Catalysts for Heterocyclic Synthesis

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