Recent progress in the field of multicomponent bioactive nanostructured films

Abstract

Multicomponent bioactive nanostructured films (MuBiNaFs) with an excellent combination of chemical, mechanical, tribological, and biological properties were developed and deposited by sputtering of composite targets produced via the self-propagating high-temperature synthesis method. Reviewed substrate materials included Ti-, Ni-, and Co-based alloys, insoluble polymers, and deimmunized donor's bones. Our results showed that the MuBiNaF deposition can be effectively combined with either a bulk

Toward bioactive yet antibacterial surfaces

“…In this work, multicomponent bioactive nanostructured TiCaPCON films were chosen as the basic material for further modifications in order to develop more advanced biocoatings which are biocompatible, bioactive, and antibacterial [14]. They were doped with Ag via two different ways: by sputtering of metallic Ag target and by high-energy Ag + ion implantation.…”

In vitro bioactivity study of TiCaPCO(N) and Ag‐doped TiCaPCO(N) films in simulated body fluid

“…Compared with crystallized HA, which showed essentially bioinert characteristics, amorphous CaP and CaO phases demonstrated enhanced solubility in human blood and SBF . In the present study, the near‐surface local supersaturation could be achieved via easy release of calcium and phosphate ions from amorphous component of the MS TiCaPCON and TiCaPCON–Ag films . Note that while some level of supersaturation at the implant–tissue interface is important for bone remodeling, an excessive amount of Ca 2+ and ions released from the dissolving film surface may result in negative effects on living bone cells …”

“…It was proposed that bioactivity can be indeed tested in SBF only assuming that there is a correlation between a material in vitro and in vivo behavior. In view of this argument, our recent in vivo studies on TiCaPCON‐coated Ti implants should be mentioned . After one month of implantation, a close contact between the implant surface and cortical bone was observed without any bone loss at the interface.…”

Fabrication method, structure, mechanical, and biological properties of decellularized extracellular matrix for replacement of wide bone tissue defects

“…This approach, however, requires additional efforts to provide good cell adhesion with DECMs. In this context, a promising solution might be the fabrication of a hybrid DECM coated with multicomponent bioactive nanostructured films (Shtansky et al, 2013) which decrease material's biodegradation and improve its mechanical characteristics. Such studies are now underway.…”