Recent Progress in Pharmacological Studies on Bile Acids*,**From Riedel‐de Haen, Inc., New York, N. Y.†This is the eighth of a series of review articles. Part of the cost of publication of this series of review articles is paid from the treasury of the National Conference on Pharmaceutical Research.

HAEN, PAUL de

doi:10.1002/jps.3030330601

Journal of the American Pharmaceutical Association (Scientific

1944

DOI: 10.1002/jps.3030330601

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Recent Progress in Pharmacological Studies on Bile Acids*,**From Riedel‐de Haen, Inc., New York, N. Y.†This is the eighth of a series of review articles. Part of the cost of publication of this series of review articles is paid from the treasury of the National Conference on Pharmaceutical Research.

PAUL de HAEN¹

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Cited by 13 publications

References 62 publications

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Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Bottari

Festa

2005

Annali di Chimica

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Composition and existence range of aggregates formed by sodium glycocholate and glycodeoxycholate contemporary present in aqueous micellar and premicellar solutions were investigated. Solubility measurements of lead (II) glycocholate and glycodeoxycholate give analytical concentration of lead (II) and glycocholate and glycodeoxycholate, respectively. Electromotive force measurements provide the free concentration of hydrogen, sodium and lead (II) ions. Experimental data obtained at 25 degrees C and at three different concentrations of N(CH3)4Cl, used as a constant ionic medium, can be explained by assuming the presence of aggregates of different composition depending on the reagent and ionic medium concentrations. Next to two species containing only glycocholate or glycodeoxycholate, the presence of aggregates formed with the contemporary participation of both bile anions in different ratios was assumed. Species with the hydrogen ion participation are not present in appreciable quantity in the investigated concentration range. As expected, the size of aggregates increases by increasing reagent and ionic medium concentration. Most of the species can be explained with a "core + link" mechanism, where all the glycocholate aggregation numbers are even, while those of glycodeoxycholate are always multiple of three. Analogy and difference with aggregates formed by the two bile anions separately are discussed.

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Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Bottari

Festa

2005

Annali di Chimica

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Taurocholate and Taurodeoxycholate: Gel Formation and Protonation Constants

2006

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Taurocholate (TC) and taurodeoxycholate (TDC) in aqueous solutions, in the presence of sodium and hydrogen ions can give micellar products, even differently protonated. This phenomenon is investigated in this paper to explain whether the assumption of hydrogen ions is to attribute to the micellar aggregates, or to the protonation of taurocholate and taurodeoxycholate, respectively.In the course of this research, often the formation of gel occurred immediately after the mixture of the reagents (sodium, hydrogen ions and anions of bile acids) or after some time, depending on the concentrations of the reagents. No author mentions this evidence, but experiments carried out in the presence of gel are not reproducible because the investigated solutions cannot be considered in real equilibrium.The protonation study was performed by means of electromotive force measurements of a galvanic cell involving a glass electrode, at 25°C and 1.00 mol dm‐3 NaCl, as ionic medium. The obtained protonation constants had the following values: log k1 = 0.07 ± 0.02 for TC and log k'1 = 1.60 ± 0.03 for TDC.

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On the composition of sodium glycodeoxycholate micellar solutions

Bottari

Festa

1993

Monatsh Chem

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Cited by 13 publications

References 62 publications

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Taurocholate and Taurodeoxycholate: Gel Formation and Protonation Constants

On the composition of sodium glycodeoxycholate micellar solutions

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