On the composition of sodium glycodeoxycholate micellar solutions

Bottari, Emilio; Festa, Maria Rosa

doi:10.1007/bf00810020

Cited by 19 publications

(45 citation statements)

References 13 publications

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“…Work solutions of tetramethylammonium glycocholate and glycodeoxycholate were prepared by adding a slight excess of tetramethylammonium hydroxide solution (Riedel de Haën) to a weighted quantity of glycocholic or glycodeoxycholic acid, respectively with continuous stirring and under a stream of nitrogen. 18,21 Preparation and analysis of solid lead (II) glycocholate and glycodeoxycholate were carried out as described previously. 24,25 Also work solutions of HCl, NaCl, tetramethylammonium hydroxide and tetramethylammonium chloride were prepared and analysed as described earlier.…”

Section: Reagents and Analysismentioning

confidence: 99%

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Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Bottari

Festa

2005

Annali di Chimica

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Composition and existence range of aggregates formed by sodium glycocholate and glycodeoxycholate contemporary present in aqueous micellar and premicellar solutions were investigated. Solubility measurements of lead (II) glycocholate and glycodeoxycholate give analytical concentration of lead (II) and glycocholate and glycodeoxycholate, respectively. Electromotive force measurements provide the free concentration of hydrogen, sodium and lead (II) ions. Experimental data obtained at 25 degrees C and at three different concentrations of N(CH3)4Cl, used as a constant ionic medium, can be explained by assuming the presence of aggregates of different composition depending on the reagent and ionic medium concentrations. Next to two species containing only glycocholate or glycodeoxycholate, the presence of aggregates formed with the contemporary participation of both bile anions in different ratios was assumed. Species with the hydrogen ion participation are not present in appreciable quantity in the investigated concentration range. As expected, the size of aggregates increases by increasing reagent and ionic medium concentration. Most of the species can be explained with a "core + link" mechanism, where all the glycocholate aggregation numbers are even, while those of glycodeoxycholate are always multiple of three. Analogy and difference with aggregates formed by the two bile anions separately are discussed.

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Section: Reagents and Analysismentioning

confidence: 99%

“…(6) q = 1. On this basis, by assuming the presence of the species found previously for the systems Na -GC 21 and Na -GDC, 18 i.e. Na(GC) 2 and Na(GDC), eq.…”

Section: Preliminary Informationmentioning

confidence: 99%

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Bottari

Festa

2005

Annali di Chimica

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“…[4][5][6][7][8][9][10][11][12][13][14][15][16] The results obtained from e.m.f. measurements, carried out as a function of hydrogen ions, reagents and ionic medium 17 concentrations on aqueous sodium salt solution of dihydroxycholanic acids (deoxycholate = NaDC 18 , glycodeoxycholate = NaGDC 19 and taurodeoxycholate = NaTDC 20 ), were explained by assuming the presence of several species with different odd high aggregation numbers and also formed with the uptake of protons. In all cases the presence of a trimer, which seems to constitute the micellar aggregates building unit, is observed for all the ionic medium concentrations.…”

Section: Introductionmentioning

confidence: 99%

Composition of Sodium Cholate Micellar Solutions

Bottari¹,

Buonfigli²,

Festa³

2005

Annali di Chimica

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To study the composition of sodium cholate solutions, an investigation was carried out at 25 degrees C and in N(CH3)4Cl, as a constant ionic medium, at three different concentrations (W = 0.100; 0.500 and 0.800 mol dm(-3)). Electromotive force measurements of three different galvanic cells, the first involving a glass electrode for hydrogen ions, the second an electrode for sodium ions and the third a lead amalgam electrode, were performed. Independently, lead (II) cholate solubility measurements in the presence of sodium ions were performed, as well. The experimental results obtained from both approaches were explained by assuming the formation of aggregates in cholate and sodium of different composition depending on W and on the cholate concentration. The maximum aggregation found number for cholate was 24 and even aggregation numbers were markedly predominant. Only two species with odd aggregation number were found, but at a low percentage. The assumed species and the relative constants were compared with those found for the other sodium salt of cholanic acids.

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“…measurements as a function of hydrogen ion and reagent concentration. [6][7][8][9][10][11] Reagent activity coefficients were kept constant, in spite of a wide change of concentrations, adopting the constant ionic medium method. 12 N(CH 3 ) 4 Cl at different concentrations was selected as an ionic medium considered inert.…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Ionic Medium on the Behaviour of Sodium Glycocholate and Cholate Aqueous Solutions

2005

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In the framework of research on the sodium bile salts, solutions of sodium cholate and glycocholate had been studied only at three ionic medium concentrations. In this paper, experiments in two other concentrations of ionic medium are carried out both to verify the behaviour dependence on the ionic medium and to apply the results of this paper to a future investigation on solutions containing contemporary sodium cholate and glycocholate. To this aim, solubility, protonation constants, lead (II) salts solubility products at 25 degrees C and in 0.300 and 0.750 mol dm(-3) N(CH3)4Cl were determined. The formed species in solutions containing lead (II) together with the selected bile salts and the behaviour of the sodium salts in micellar and premicellar solutions were investigated, too. The obtained results were compared with those obtained at the other ionic medium concentrations.

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On the composition of sodium glycodeoxycholate micellar solutions

Cited by 19 publications

References 13 publications

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Composition of Aqueous Solutions Containing Sodium Glycocholate and Glycodeoxycholate

Composition of Sodium Cholate Micellar Solutions

The Influence of the Ionic Medium on the Behaviour of Sodium Glycocholate and Cholate Aqueous Solutions

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