Recent developments in functionalized polymer nanoparticles for efficient drug delivery system

Sur, Srija; Rathore, Aishwarya; Dave, Vivek; Reddy, Kakarla Raghava; Chouhan, Raghuraj Singh; Sadhu, Veera

doi:10.1016/j.nanoso.2019.100397

Cited by 371 publications

(209 citation statements)

References 89 publications

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“…Enormous amounts of research and exploration of disorders and diseases have helped us to achieve an appropriate dosage system to stabilize a patient’s health [ 1 , 2 ]. Conventional drug delivery systems such as salting-out (salting-out agent required), supercritical fluid technology (capillary nozzle and a supercritical fluid required), dialysis (capillary nozzle and a supercritical fluid required), solvent evaporation (surfactant required), and nanoprecipitation (non-solvent for the polymer required) are also used [ 1 ]. Moreover, conventional drug delivery systems have several deficiencies such as reduced patient compliance, shorter half-life of drugs, and high peak, etc.…”

Section: Introductionmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

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Section: Introductionmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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“…As has been well documented, efficient drug delivery carriers should not only be biocompatible to ensure safety aspects of nano delivery vehicles, but also be suitable to stabilize and protect biomolecules against harsh physical and biochemical attacks in biological environments, subsequently to deliver genes/drugs into the target-specific tissue and release them in the controlled manner. To date, as nonviral vectors, micelles, liposomes, and polymer-based nano delivery carriers have been developed as up-to-date drug delivery systems (DDSs) [45][46][47][48][49][50][51][52][53][54], but they are inherently [3,12,17]. Images in parts 'hydrotalcite-Talcid ® ' courtesy of Bayer, Germany and Gattefosse, France.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

et al. 2020

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Biocompatible hydrotalcite nanohybrids, i.e., layered double hydroxide (LDH) based nanohybrids have attracted significant attention for biomedical functions. Benefiting from good biocompatibility, tailored drug incorporation, high drug loading capacity, targeted cellular delivery and natural pH-responsive biodegradability, hydrotalcite nanohybrids have shown great potential in drug/gene delivery, cancer therapy and bio-imaging. This review aims to summarize recent progress of hydrotalcite nanohybrids, including the history of the hydrotalcite-like compounds for application in the medical field, synthesis, functionalization, physicochemical properties, cytotoxicity, cellular uptake mechanism, as well as their related applications in biomedicine. The potential and challenges will also be discussed for further development of LDHs both as drug delivery carriers and diagnostic agents.

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“…Alginate is a polyanion, typically obtained from brown seaweed, that possesses solubility in water, great biocompatibility and low toxicity and is biodegradable and of relatively low cost. Most alginates can be processed in the form of hydrogels, porous scaffolds, microparticles and nanoparticles [40]. Alginates are readily degraded by naturally occurring enzymes, i.e., lysases.…”

Section: Alginatementioning

confidence: 99%

“…Their physical and mechanical properties are dependent on the length, molecular weight and proportion of the guluronate block within the polymeric chain [41,42]. Alginates can be prepared by various cross-linking methods in a similar way to the extracellular matrix of living tissue, making them desirable for applications in wound healing, drug delivery, and cell transplantation [40,43].…”

Section: Alginatementioning

confidence: 99%

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

et al. 2020

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structure, and controlled mechanical strength. Additionally, biodegradable constructs are also very sought-out for biomolecule delivery systems with a target-directed action. In the present review, we explore the properties of some of the most common biodegradable polymers used in tissue engineering applications and biomolecule delivery systems and highlight their most important uses.

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Recent developments in functionalized polymer nanoparticles for efficient drug delivery system

Cited by 371 publications

References 89 publications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Biocompatible Hydrotalcite Nanohybrids for Medical Functions

Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems

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