A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Idrees, Humaira; Zaidi, Syed Zohaib Javaid; Sabir, Aneela; Khan, Rafi Ullah; Zhang, Xunli; Hassan, Sammer-ul

doi:10.3390/nano10101970

Cited by 198 publications

(123 citation statements)

References 126 publications

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“…Chitosan nanoparticles are synthesized for different purposes by various methods, such as ionotropic gelation, polyelectrolyte complexation, emulsification solvent diffusion, microemulsion, and reverse micelle formation [ 204 , 205 ]. Moreover, the antimicrobial effects of chitosan-based nanoparticles for drug and drug-free delivery systems have been intensively investigated against bacteria and fungi [ 56 , 57 , 58 , 60 , 63 , 67 , 68 , 106 , 119 , 203 , 206 , 207 , 208 , 209 , 210 , 211 , 212 ]. For example, chitosans of different DDAs and MWs exhibited synergistic activity with sulfamethoxazole against P. aeruginosa [ 213 ].…”

Section: Applications Of Chitosan-based Nanoparticles and Films Inmentioning

confidence: 99%

Antimicrobial Actions and Applications of Chitosan

et al. 2021

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Chitosan is a naturally originating product that can be applied in many areas due to its biocompatibility, biodegradability, and nontoxic properties. The broad-spectrum antimicrobial activity of chitosan offers great commercial potential for this product. Nevertheless, the antimicrobial activity of chitosan varies, because this activity is associated with its physicochemical characteristics and depends on the type of microorganism. In this review article, the fundamental properties, modes of antimicrobial action, and antimicrobial effects-related factors of chitosan are discussed. We further summarize how microorganisms genetically respond to chitosan. Finally, applications of chitosan-based biomaterials, such as nanoparticles and films, in combination with current clinical antibiotics or antifungal drugs, are also addressed.

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Section: Applications Of Chitosan-based Nanoparticles and Films Inmentioning

confidence: 99%

Antimicrobial Actions and Applications of Chitosan

et al. 2021

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“…Among the various types of drug delivery systems, polymeric nanoparticles have enormous potential as an effective drug delivery system. Polymeric nanoparticles are submicron colloidal particles consisting of different biodegradable materials such as natural or synthetic polymers [ 20 , 21 ]. Polymeric nanoparticles can efficiently carry and deliver both hydrophilic or hydrophobic drugs and imaging agents to targeted sites [ 20 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells

Saqr

Wani²,

Gangadharappa

et al. 2021

Polymers

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Despite decades of research, breast cancer therapy remains a great challenge. Docetaxel is an antimicrotubule agent that is effectively used for the treatment of breast cancer. However, its clinical use is significantly hampered by its low water solubility and systemic toxicity. The current study was designed to prepare docetaxel (DXL)-loaded silk-fibroin-based nanoparticles (SF-NPs) and to screen their potential antitumor activity against breast cancer cell lines. DXL-loaded SF-NPs were prepared using a nanoprecipitation technique and were evaluated for particle size, zeta potential, entrapment efficiency, and in vitro release profile. In addition, DXL-loaded SF-NPs were screened for in vitro cytotoxicity, cellular uptake, and apoptotic potential against MCF-7 and MDA-MB-231 breast cancer cell lines. The prepared DXL-loaded SF-NPs were 178 to 198 nm in diameter with a net negative surface charge and entrapment efficiency ranging from 56% to 72%. In vitro release studies exhibited a biphasic release profile of DXL from SF-NPs with sustained drug release for 72 h. In vitro cell studies revealed that entrapment of DXL within SF-NPs significantly improved cytotoxic potential against breast cancer cell lines, compared to the free drug, and enhanced cellular uptake of DXL by breast cancer cells. Furthermore, the accumulation in the G2/M phase was significantly higher in cells treated with DXL-loaded SF-NPs than in cells treated with free DXL. Collectively, the superior antitumor activities of DXL-loaded SF-NPs against breast cancer cells, compared to free DXL, could be ascribed to improved apoptosis and cell cycle arrest. Our results highlighted the feasibility of using silk fibroin nanoparticles as a nontoxic biocompatible delivery vehicle for enhanced therapeutic outcomes in breast cancer.

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“…To date, the wide availability of materials and preparation methods allows for a large number of nanoparticle architectures to be obtained endowed with different targeting ligands and stimuli-responsive chemical groups. Natural polymers, such as polysaccharides and proteins, have emerged as promising base materials of drug delivery platforms in cancer therapy due to their unique physicochemical and biological properties such as nonimmunogenicity, biocompatibility, biodegradability, and the presence of several functional groups available for chemical modification [12]. Protein nanoparticles can be prepared under mild conditions without the use of toxic chemicals or organic solvents, allowing to easily control the particle size [13,14]; on the other hand, polysaccharide materials are safe and may confer "stealth" properties to the final nanoparticle system, decreasing the uptake by the mononuclear phagocyte system and enhancing the blood circulation time and the possibility of accumulation in the disease site [15].…”

Section: Introductionmentioning

confidence: 99%

Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin

et al. 2021

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Drug targeting of tumor cells is one of the great challenges in cancer therapy; nanoparticles based on natural polymers represent valuable tools to achieve this aim. The ability to respond to environmental signals from the pathological site (e.g., altered redox potential), together with the specific interaction with membrane receptors overexpressed on cancer cells membrane (e.g., CD44 receptors), represent the main features of actively targeted nanoparticles. In this work, redox-responsive micelle-like nanoparticles were prepared by self-assembling of a hyaluronic acid–human serum albumin conjugate containing cystamine moieties acting as a functional spacer. The conjugation procedure consisted of a reductive amination step of hyaluronic acid followed by condensation with albumin. After self-assembling, nanoparticles with a mean size of 70 nm and able to be destabilized in reducing media were obtained. Doxorubicin-loaded nanoparticles modulated drug release rate in response to different redox conditions. Finally, the viability and uptake experiments on healthy (BALB-3T3) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a drug vector in cancer therapy.

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A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Cited by 198 publications

References 126 publications

Antimicrobial Actions and Applications of Chitosan

Antimicrobial Actions and Applications of Chitosan

Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells

Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin

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