Recent Developments in Coatings for Orthopedic Metallic Implants

Hussain, Muzamil; Rizvi, Syed Hasan Askari; Abbas, Naseem; Sajjad, Uzair; Shad, Muhammad Rizwan; Badshah, Mohsin Ali; Malik, Asif Iqbal

doi:10.3390/coatings11070791

Cited by 36 publications

(32 citation statements)

References 150 publications

(89 reference statements)

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“…As metallic biomaterials represent key elements for hard tissue replacement and restoration, a plethora of efforts have been undertaken to limit their main shortcomings, namely bioinertness and poor bioactivity. Many studies confirmed the importance of surface characteristics for reaching a proper and augmented osseointegration [10][11][12][13], with a special emphasis forming a bioactive implant-to-bone interface.…”

Section: Introductionmentioning

confidence: 90%

Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Gherasim

Grumezescu

et al. 2021

Polymers

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Osteoconductive and osteoinductive coatings represent attractive and tunable strategies towards the enhanced biomechanics and osseointegration of metallic implants, providing accurate local modulation of bone-to-implant interface. Composite materials based on polylactide (PLA) and hydroxyapatite (HAp) are proved beneficial substrates for the modulation of bone cells’ development, being suitable mechanical supports for the repair and regeneration of bone tissue. Moreover, the addition of osteogenic proteins represents the next step towards the fabrication of advanced biomaterials for hard tissue engineering applications, as their regulatory mechanisms beneficially contribute to the new bone formation. In this respect, laser-processed composites, based on PLA, Hap, and bone morphogenetic protein 4(BMP4), are herein proposed as bioactive coatings for metallic implants. The nanostructured coatings proved superior ability to promote the adhesion, viability, and proliferation of osteoprogenitor cells, without affecting their normal development and further sustaining the osteogenic differentiation of the cells. Our results are complementary to previous studies regarding the successful use of chemically BMP-modified biomaterials in orthopedic and orthodontic applications.

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Section: Introductionmentioning

confidence: 90%

Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Gherasim

Grumezescu

et al. 2021

Polymers

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“…These can be either nitinol-based and composites thereof [ 151 , 152 ] or more unusual coating materials such as hardystonite [ 153 ]. Some examples of such coatings were recently reviewed by Hussain et al [ 154 ].…”

Section: Coating Materials Selectionmentioning

confidence: 99%

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Mastnak

Maver

Finšgar

2022

IJMS

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The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgical outcome. The objective of this work is to provide a review of several groups of biocompatible materials that might be utilized as constituents for the development of multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving, and anticoagulant properties. Moreover, the review presents a summary of medications used in clinical settings, the disadvantages of the commercially available products, and insight into the latest development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of the surface treatment should be considered in the development process.

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“…Conventional materials suggested as coatings on titanium for enhanced biocompatibility include hydroxyapatite, bioactive glass, biphasic calcium phosphate and TiN. However, the stability, adhesion, and degradation performance of these coatings are still challenging [4,5]. The drawbacks and limited performance can be partly attributed to the quality and coverage of coatings which has a direct effect on responses such as initial cellular adhesion to a substrate, subsequent growth and proliferation, and bioactivity of material [6].…”

Section: Introductionmentioning

confidence: 99%

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

Zalieckas

Mondragon

Pobedinskas

et al. 2022

Preprint

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Polycrystalline diamond has the potential to improve the osseointegration of orthopaedic implants compared to conventional materials such as titanium. However, despite the excellent biocompatibility and superior mechanical properties, the major challenge of using diamond for implants, such as those used for hip arthroplasty, is the limitations of microwave plasma chemical vapor deposition (CVD) techniques to synthesize diamond on complex-shaped objects. Here, for the first time we demonstrate diamond growth on titanium acetabular shells using surface wave plasma CVD method. Polycrystalline diamond coatings were synthesized at low temperatures (~400 °C) on three types of acetabular shells with different surface structure and porosity. We achieved the growth of diamond on highly porous surfaces designed to mimic the structure of the trabecular bone and improve osseointegration. Biocompatibility was investigated on nanocrystalline diamond (NCD) and ultrananocrystalline diamond (UNCD) coatings terminated either with hydrogen or oxygen. To understand the role of diamond surface topology and chemistry in the attachment and proliferation of mammalian cells, we investigated the adsorption of extracellular matrix (ECM) proteins, and monitored the metabolic activity of fibroblasts, osteoblasts, and bone marrow-derived mesenchymal stem cells (MSCs). The interaction of bovine serum albumin (BSA) and Type I collagen with the diamond surfaces was investigated by confocal fluorescence lifetime imaging microscopy (FLIM). We found that the proliferation of osteogenic cells was better on hydrogen terminated UNCD than on the oxygen terminated counterpart. These findings correlated with the behaviour of collagen on diamond substrates observed by FLIM. Hydrogen terminated UNCD provided better adhesion and proliferation of osteogenic cells, compared to titanium, while growth of fibroblasts was poorest on hydrogen terminated NCD and MSCs behaved similarly on all tested surfaces. These results open new opportunities for application of diamond coatings on orthopaedic implants.

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Recent Developments in Coatings for Orthopedic Metallic Implants

Cited by 36 publications

References 150 publications

Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Polycrystalline Diamond Coating on Orthopaedic Implants: Realization, and Role of Surface Topology and Chemistry in Adsorption of Proteins and Cell Proliferation

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