Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Gherasim, Oana; Grumezescu, Alexandru Mihai; Grumezescu, Valentina; Andronescu, Ecaterina; Neguț, Irina; Bîrcă, Alexandra Cătălina; Gălățeanu, Bianca; Hudiţă, Ariana

doi:10.3390/polym13244303

Cited by 12 publications

(5 citation statements)

References 88 publications

(99 reference statements)

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“…Following their sequential investigation, FT-IR analysis demonstrated the efficient fabrication of composite formulations ( Figure 2 ). For instance, the signature ester of PLA was identified at ~1680 cm −1 , a slightly shifted position when compared to other PLA-based formulations [ 76 , 77 , 78 ]. This was particularly assigned to the vibrations of the hydrogen-bounded carbonyl, which resulted in entrapping the H 2 O 2 within the polymer matrix.…”

Section: Discussionmentioning

confidence: 95%

H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing

et al. 2023

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Hydrogel-based dressings exhibit suitable features for successful wound healing, including flexibility, high water-vapor permeability and moisture retention, and exudate absorption capacity. Moreover, enriching the hydrogel matrix with additional therapeutic components has the potential to generate synergistic results. Thus, the present study centered on diabetic wound healing using a Matrigel-enriched alginate hydrogel embedded with polylactic acid (PLA) microspheres containing hydrogen peroxide (H2O2). The synthesis and physicochemical characterization of the samples, performed to evidence their compositional and microstructural features, swelling, and oxygen-entrapping capacity, were reported. For investigating the three-fold goal of the designed dressings (i.e., releasing oxygen at the wound site and maintaining a moist environment for faster healing, ensuring the absorption of a significant amount of exudate, and providing biocompatibility), in vivo biological tests on wounds of diabetic mice were approached. Evaluating multiple aspects during the healing process, the obtained composite material proved its efficiency for wound dressing applications by accelerating wound healing and promoting angiogenesis in diabetic skin injuries.

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Section: Discussionmentioning

confidence: 95%

H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing

et al. 2023

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“…The interface of bone and implant is a constantly changing entity, with diverse microscopic features observed on different parts of the implant's surface [56]. Direct attachment to mineralized bone can be seen in some regions, while in others, a delicate unmineralized matrix acts as a separator between the bone and the implant.…”

Section: Dynamic Responsive Surfacesmentioning

confidence: 99%

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

Vasile,

Pirvulescu,

Iancu

et al. 2024

Materials

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With the increasing incidences of orbital wall injuries, effective reconstruction materials and techniques are imperative for optimal clinical outcomes. In this literature review, we delve into the efficacy and potential advantages of using titanium implants coated with nanostructured hydroxyapatite for the reconstruction of the orbital wall. Titanium implants, recognized for their durability and mechanical strength, when combined with the osteoconductive properties of hydroxyapatite, present a potentially synergistic solution. The purpose of this review was to critically analyze the recent literature and present the state of the art in orbital wall reconstruction using titanium implants coated with nanostructured hydroxyapatite. This review offers clinicians detailed insight into the benefits and potential drawbacks of using titanium implants coated with nanostructured hydroxyapatite for orbital wall reconstruction. The highlighted results advocate for its benefits in terms of osseointegration and provide a novel strategy for orbital reconstruction, though further studies are essential to establish long-term efficacy and address concerns.

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“…Physical, chemical, mechanical, or electrical signals [8,9]. The interaction between the mentioned elements is directly related to the chemical and topographic characteristics of the scaffold (similar to the extracellular matrix), which will act as a physical layer for cell development and differentiation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Cell-Based Tissue Engineering for Guided Bone Regeneration in Rats: A Preliminary Study with 3D-Printed β-Tricalcium Phosphate Scaffolds and Polydioxanone Membranes

Pitol-Palin,

Moura,

Frigério

et al. 2024

Preprint

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Treatment of complex craniofacial deformities is still a challenge for medicine and dentistry because few approach therapies are available on the market that allows rehabilitation using 3D-printed medical devices. Thus, this preliminary study aims to evaluate the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds and polydioxanone membrane (PDO) with cell-based (ASCs) tissue engineering for guided bone regeneration in critical calvary defects of rats. Methods: Male rats were divided into three groups: β-TCP + PDO membrane (TCP/PG), β-TCP/ASCs + PDO membrane (TCPasc/PG), and β-TCP/ASCs + PDO membrane/ASCs (TCPasc/PGasc). A surgical defect in the right parietal bone was made, and the defect was filled with the 3D-printed β-TCP scaffold and PDO membrane with or without ASCs. The animals were euthanized 7, 14, and 30 days after the surgical procedure for histomorphometric and immunolabeling analyses. Results: Cell-based therapy promotes, especially in the TCPasc/PGasc group, a bone area formation at the defect border region and the center of the defect. Conclusions: Using 3D-printed β-TCP scaffolds and PDO membranes associated with cell-based therapy has excellent potential to improve and accelerate guided bone regeneration. Moreover, using ASCs optimized the bioceramics by increasing its osteoinductive and osteoprogenitor capacity even with the resorption of the printed scaffold.

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Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Cited by 12 publications

References 88 publications

H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing

H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel® Promotes Diabetic Wound Healing

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

Cell-Based Tissue Engineering for Guided Bone Regeneration in Rats: A Preliminary Study with 3D-Printed β-Tricalcium Phosphate Scaffolds and Polydioxanone Membranes

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