2022
DOI: 10.3390/ijms23052786
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Addressing the Needs of the Rapidly Aging Society through the Development of Multifunctional Bioactive Coatings for Orthopedic Applications

Abstract: The unprecedented aging of the world’s population will boost the need for orthopedic implants and expose their current limitations to a greater extent due to the medical complexity of elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with multifunctional bioactive coatings promise to provide the means for the controlled and tailorable release of different medications for patient-specific treatment while prolonging the material’s lifespan and thus improving the surgic… Show more

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Cited by 15 publications
(13 citation statements)
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References 245 publications
(225 reference statements)
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“…25,26 Polymers of various classes, including naturally occurring polymers, synthetic polymers, and inorganic coating materials can be used as carrier material to prepare the coating solution. 27 Biodegradable polymers like PLGA(Poly lactide-co-glycolide) are the polymers of choice for such coating due to their biocompatibility, established safety, controllable release rate, and easy resorption inside the body after installation. 28−30 The PLGA-drug mixed coat acts as a matrix vehicle on the metal surface for therapeutic benefits of active agents and also assists with corrosion resistance, 31 wettability, 32 biocompatibility, 33 and osteointegration.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…25,26 Polymers of various classes, including naturally occurring polymers, synthetic polymers, and inorganic coating materials can be used as carrier material to prepare the coating solution. 27 Biodegradable polymers like PLGA(Poly lactide-co-glycolide) are the polymers of choice for such coating due to their biocompatibility, established safety, controllable release rate, and easy resorption inside the body after installation. 28−30 The PLGA-drug mixed coat acts as a matrix vehicle on the metal surface for therapeutic benefits of active agents and also assists with corrosion resistance, 31 wettability, 32 biocompatibility, 33 and osteointegration.…”
Section: Introductionmentioning
confidence: 99%
“…Various coating techniques have been explored to investigate their potential in preventing PSIs and implant-related infections, including electrospun coatings, electrophoretic deposition, lipid-based coating, spin-coating, plasma spraying, layer upon-layer addition, and 3D-printing based coatings . Among these techniques, multilayered loading has been actively investigated by utilizing an innovative airbrush technique appropriate for volatile organic-based solutions and slurries to form uniform coat layers on the implant surface. , Polymers of various classes, including naturally occurring polymers, synthetic polymers, and inorganic coating materials can be used as carrier material to prepare the coating solution . Biodegradable polymers like PLGA­(Poly lactide- co -glycolide) are the polymers of choice for such coating due to their biocompatibility, established safety, controllable release rate, and easy resorption inside the body after installation. The PLGA-drug mixed coat acts as a matrix vehicle on the metal surface for therapeutic benefits of active agents and also assists with corrosion resistance, wettability, biocompatibility, and osteointegration …”
Section: Introductionmentioning
confidence: 99%
“…The ever-increasing number of hard tissue injuries and diseases, as a result of modern lifestyle and the aging population, motivates the research and development of novel bioimplant materials. 1,2 From the increased understanding of bone formation and biology on the one hand, and the problems related to implantation procedures, especially implant associated infections (IAIs), on the other hand, it became clear that implants should perform multiple functions. 2 They should be bioactive, allow good osseointegration, and have antimicrobial properties, to name just a few of the requirements.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 From the increased understanding of bone formation and biology on the one hand, and the problems related to implantation procedures, especially implant associated infections (IAIs), on the other hand, it became clear that implants should perform multiple functions. 2 They should be bioactive, allow good osseointegration, and have antimicrobial properties, to name just a few of the requirements. 3,4 Since no single material can fulll all these requirements, the solution is sought in composite materials.…”
Section: Introductionmentioning
confidence: 99%
“…However, the clinical use of heparin is limited by the risk of hemorrhage, excessive bleeding, and heparin-induced thrombocytopenia. Consequently, considerable efforts have been made in recent years to create safer anticoagulant materials without hemorrhagic complications . Recently, heparin mimetic or polysaccharides that have sulfate groups and anticoagulant biomaterials have also been applied as surface modification materials .…”
Section: Introductionmentioning
confidence: 99%