Recent developments in anti‐inflammatory natural products

Abstract

Many of the inflammatory diseases are becoming common in aging society throughout the world. The clinically used anti-inflammatory drugs suffer from the disadvantage of side effects and high cost of treatment (in case of biologics). Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Since ancient times traditional medicines and phytopharmaceuticals are being used for the treatment of inflammatory and other disorders. The present review article describes anti-inflammatory natural products derived from plants and marine sources reported during last decade. The compounds described belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds. The attempt is also being made to enumerate the possible leads, e.g. curcumin, resveratrol, baicalein, boswellic acid, betulinic acid, ursolic acid, and oleanolic acid, for further development with the help of structure-activity relationship (SAR) studies and their current status. In addition SAR studies carried out on the anti-inflammatory activity of flavonoid compounds and clinical studies performed on anti-inflammatory natural products are also discussed.

Evaluation of the in vitro Anti-inflammatory Activity of Nerium oleander L. Flower Extracts and Activity-Guided Isolation of the Active Constituents

“…However, chronic inflammation contributes crucially to the pathogenesis of many diseases including inflammatory bowel diseases, asthma, arthiritis as well as neurodegenerative diseases (e.g. Alzheimer's disease, multiple sclerosis) [1][2][3][4][5][6]. Such disorders are very common and constitute the main health problems of the worldwide society [7][8][9][10].…”

Biologically active secondary metabolites from Asteraceae and Polygonaceae species

“…[5][6][7] Cannabidiol, a secondary metabolite in Cannabis sativa has also been approved for the treatment of inflammation in many countries (e.g. Germany, the UK, Canada and New Zealand) in 2005.…”

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

“…An urgent need to understand the various factors that contribute to and accelerate disease progression to an irreversible chronic stage need to be tackled with a variety of combined approaches [4,5]. Extensive research from our laboratory and that of others have provided ample evidence that bioactive phytochemicals present in spices, fruits, seeds, and cruciferous vegetables have shown the potential to prevent inflammation-driven diseases [3,[6][7][8]. Overwhelming evidence also suggests that consumption of fruits, vegetables and medicinal plants rich in triterpenoids have shown beneficial effects against a variety of inflammation-driven diseases, including cancer of the breast, prostate, colon, lung, liver, kidney and the pancreas [2,9].…”