Biologically active secondary metabolites from Asteraceae and Polygonaceae species

Lajter, Ildikó

doi:10.14232/phd.2817

Cited by 3 publications

(6 citation statements)

References 72 publications

(78 reference statements)

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“…Apigenin and luteolin were isolated from the aerial part of O. acanthium in the amount of 4.5 mg per 4.4 kg of dry raw materials. They are also found in the leaves and flowers [ 22 , 23 , 24 , 25 ].…”

Section: Chemical Compositionmentioning

confidence: 99%

“…4’-methyl ether of scutellarein (6-hydroxy apigenin) was found in leaves in the amount of 9.5 mg per 215 g of dry leaves [ 26 ]. Other methoxy derivatives (nepetin, chrysoeriol, hispidulin, pectolinarigenin) were detected in the aerial part in the amount of 8.0 mg/4.4 kg dry raw material (nepetin), 3.5 mg/4.4 kg dry raw material (hispidulin), as well as in leaves and 1.6 mg/215 g dry weight (pectolinarigenin) and flowers (chrysoeriol) [ 23 , 24 , 25 , 26 ].…”

Section: Chemical Compositionmentioning

confidence: 99%

“…Lajter [ 24 , 25 , 31 ] isolated lignans such as pinoresinol (5.5 mg/4.4 kg air-dried herb), syringaresinol (9.4 mg/4.4 kg air-dried herb) and medioresinol (3.4 mg/4.4 kg air-dried herb) ( Table 2 ).…”

Section: Chemical Compositionmentioning

confidence: 99%

“…The roots of O. acanthium contain nitidanin diisovalerianate [ 24 , 25 , 31 ]. Daci [ 29 ] found in methanol extract of achenes 87 ± 2% (by volume) or 38.0 ± 3.2 mg/g of fresh fruits of arctiin ( Figure 4 ).…”

Section: Chemical Compositionmentioning

confidence: 99%

“…In fatty oil, free sterols were found: β-sitosterol, campesterol, traces of sitosterol and stigmasterol [ 39 ]. In roots, stigmasterol, β-sitosterol, and 24-methylenecholesterol were found ( Table 4 ) [ 24 , 25 , 31 ].…”

Section: Chemical Compositionmentioning

confidence: 99%

See 4 more Smart Citations

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Robertovna

Konovalov

Shamilov

et al. 2019

Plants

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For many years, plants have been used in the traditional medicine of different cultures. The biennial plant of the family Asteraceae, Onopordum acanthium L., also known as Scotch thistle, is used in traditional medicine as an anti-inflammatory, antitumor, and cardiotonic agent. The plant is widespread in the world; it grows in Europe and Asia and was introduced to America and Australia. Stems and buds of the first-year plant are used in cooking as an analogue of artichoke in European cuisine. Additionally, inflorescences contain a complex of proteolytic enzymes “onopordosin”, which may be used as a milk-clotting agent in the dairy industry. The chemical composition of the aerial part and roots of O. acanthium is represented by flavonoids, phenylpropanoids, lignans, triterpenoids, sesquiterpene lactones, and sterols. The anti-inflammatory, antiproliferative, and cardiotonic properties of the plant have been confirmed by pharmacological experiments with extracts and individual compounds using in silico, in vitro, and in vivo methods. This work is a review of information on the chemical composition and pharmacological studies of O. acanthium as a promising medicinal plant.

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Section: Chemical Compositionmentioning

confidence: 99%

Section: Chemical Compositionmentioning

confidence: 99%

Section: Chemical Compositionmentioning

confidence: 99%

Section: Chemical Compositionmentioning

confidence: 99%

Section: Chemical Compositionmentioning

confidence: 99%

See 3 more Smart Citations

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Robertovna

Konovalov

Shamilov

et al. 2019

Plants

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Traditional use, Phytochemistry and Pharmacological Properties of the Genus Onopordum

Mouffouk

et al. 2023

CCB

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Background: The genus Onopordum (Asteraceae), with about 40 species, is composed of perennials and spermatophyte plants, which are widely used in popular medicine for the treatment of several human diseases. Plants of this genus constitute an interesting source of bioactive molecules with a wide range of pharmacological applications. Objective: In this context, the current study describes a critical review of traditional uses, phytochemistry, and pharmacological effects of the genus Onopordum in order to establish a valuable database for future ethnopharmacological surveys on this genus. Methods: For this, all bibliographic data covering the period of 1970 to 2022 were collected and analyzed. Results: Only 19 species from the genus Onopordum were studied. They are traditionally used to treat gastric, renal, respiratory, urinary, and gynecological diseases and in the food industry for cheese production. Indeed, it was found that Onopordum species are rich in flavonoids, phenolic compounds, terpenoids, alkaloids, tannins, and steroids. These plants exhibit several interesting biological activities including: antioxidant, antimicrobial, antiproliferative, apoptotic, cytotoxic, antitumor, anticholinergic, larvicidal, analgesic and antipyretic, hypotensive, antiepileptic, and anticonvulsant activities. Furthermore, their hemostatic, anti-inflammatory, and moisturizing properties, increase their usefulness in the cosmetic field. Conclusion: According to the present study, Onoporadum species constitute an important natural source of secondary metabolites with potential therapeutic, cosmetic, and nutritional applications. However, the focus has been only on 19 species and the publications were not very explanatory, Therefore, in-depth pharmacological and phytochemical studies are needed to fully exploit the therapeutic potential and the chemical composition of Onopordum species.

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Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Siben

Castro

Faraoni

2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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Polyphenols are attracting increasing attention to the discovery of useful agents for the treatment of neurodegenerative diseases. Thelesperma megapotamicum (Spreng.) Kuntze belongs to the family Asteraceae which is known to have a high antioxidant capacity. The phytochemical investigation of T. megapotamicum revealed the presence of 1'-S-isobutyroxyeugenol isobutyrate (1), lupeol (2), 1'-S-acetoxyeugenol isobutyrate (3), stigmasterol (4), -sitosterol (5), eriodictyol (6), luteolin (7), and marein (8), as major secondary metabolites. The neuroprotective activity of this species was studied by evaluating the inhibition in vitro of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the antioxidant capacity of the sub-extracts and of the major metabolites isolated from them. The AChE and BChE inhibition were determined by Ellman's method and the antioxidant activity by DPPH assay. The inhibitory activity against BChE and the antioxidant capacity of the polyphenols present in T. megapotamicum highlight this species as a promising source of active metabolites for the development of agents for the treatment of neurodegenerative diseases.

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Biologically active secondary metabolites from Asteraceae and Polygonaceae species

Cited by 3 publications

References 72 publications

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Traditional use, Phytochemistry and Pharmacological Properties of the Genus Onopordum

Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

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