Recent attempts at the purification and identification of human placental “histaminase”

Kapeller‐Adler, R.

doi:10.1016/0009-8981(65)90216-0

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…The symmetrical distribution of DAO,,, in the w-zone is in agreement with a report on purified human placental 'histaminase' (6).…”

Section: Discussionsupporting

confidence: 88%

“…D A O occurs at 60" for 30 minutes but is minor compared t o what has been reported on purified human placental 'histaminase': 'very substantial loss of enzyme activity at 60"/20 min' (6). At p H 7.4 -a pH which has been reported optimal for the putrescine assay system (14)addition of histamine gave almost identical slowing of the 14C-putrescine conversion for bolth DAO,,, and DAO,,,,.…”

Section: Diamine Oxidase Isoenzymesmentioning

confidence: 76%

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Diamine Oxidase Isoenzymes in Human Blood Plasma

Hansson

1970

Scandinavian Journal of Clinical and Laboratory Investigation

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The pregnancy-induced activity of diamine oxidase (DAOpr) disappears from blood plasma after parturition with a 'half-life' (TX) of 30 hours, whereas transfused DApr is eliminated with TX about 20 hours. In contrast, the increased plasma activity of DAO in heparinized subjects (DAOhep) has a TX of about 1 hour in the eliminatory phase, and, when transfused, DAOhep is withdrawn from circulation with a TX of about 3 min. In vitro studies of DAOpr and DAOhep have shown very similar enzyme characteristics of DAODr and DAOhep, whereas they differed in electrophoretic mobility. DAOhep and DAOpr may thus be regarded as diamine oxidase isoenzymes. Scand J Clin Lab Invest Downloaded from informahealthcare.com by McMaster University on 12/26/14 For personal use only.

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“…The symmetrical distribution of DAO,,, in the w-zone is in agreement with a report on purified human placental 'histaminase' (6).…”

Section: Discussionsupporting

confidence: 88%

Section: Diamine Oxidase Isoenzymesmentioning

confidence: 76%

Diamine Oxidase Isoenzymes in Human Blood Plasma

Hansson

1970

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Indeed, a tremendous increase in diamine oxidase activity was observed in germinating legumes [13,14], in the mammalian placenta [5,[15][16][17][18] and in the blood of pregnant women [19][20][21][22][23].…”

mentioning

confidence: 99%

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

et al. 1975

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From all mammals investigated so far only in rabbits diamine oxidase could not be detected in any tissue except the gut. Thus this species was chosen for studying the physiological and pathophysiological function of this enzyme in the gastrointestinal tract. By gel filtration on Sephadex G 50 and G 200 the enzyme was purified 100-fold, separated from a soluble monoamine oxidase, and the properties of the two enzymes were determined. Diamine oxidase from rabbit small intestine deaminated putrecine (Km = 1.3 times 10(-4) M, pH-optimum 6.4-6.9) and histamine (Km = 8 times 10(-5) M, pH-optimum 7.5), but not serotonin, and was inhibited by aminoguanidine, but not by pargyline. Soluble monoamine oxidase from rabbit small intestine catabolized serotonin (Km = 1.8 times 10(-4) M, pH-optimum 8.8) but not putrescine and histamine, and was inhibited by pargyline, but not by aminoguanidine. Based on its properties in vitro intestinal diamine oxidase could inactivate the vasoactive biogenic amine histamine in vivo. To confirm this hypothesis, in rabbits the small intestine was damaged severely by inducing total intestinal ischemia, which occurs as mesenteric infarction also in human subjects and is accompanied by histamine release. Treatment with aminoguanidine and ischemia killed the animals 3-times faster than ischemia alone, which supported our hypothesis on a protective role of intestinal diamine oxidase against histamine.

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Determination of Amine Oxidases

Kapeller‐Adler

1971

Methods of Biochemical Analysis

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Recent attempts at the purification and identification of human placental “histaminase”

Cited by 9 publications

References 7 publications

Diamine Oxidase Isoenzymes in Human Blood Plasma

Diamine Oxidase Isoenzymes in Human Blood Plasma

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

Determination of Amine Oxidases

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