Diamine Oxidase Isoenzymes in Human Blood Plasma

Hansson, R.

doi:10.3109/00365517009046187

Cited by 10 publications

(4 citation statements)

References 10 publications

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“…In the nonpregnant state, this patient showed no increase in plasma histaminase activity after a 75 U/kg dose of heparin. The histaminase activity which appears in plasma during pregnancy has a different electrophoretic mobility and is cleared less rapidly from the circulation than the histaminase activity released by heparin (26). The possibility that isoenzymes of histaminase exist has been suggested (26).…”

Section: Discussionmentioning

confidence: 99%

Response of Plasma Histaminase Activity to Small Doses of Heparin in Normal Subjects and Patients with Hyperlipoproteinemia

Baylin¹,

Beaven²,

Krauss³

et al. 1973

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Response of Plasma Histaminase Activity to Small Doses of Heparin in Normal Subjects and Patients with Hyperlipoproteinemia

Baylin¹,

Beaven²,

Krauss³

et al. 1973

J. Clin. Invest.

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“…The half‐life of 90‐150 minutes for tryptase and 20‐30 hours for human DAO post‐parturition might explain the delayed increase of DAO with already decreasing tryptase concentrations in the severe anaphylaxis events . While DAO concentrations were still increasing 90 minutes after withdrawing the first sample, tryptase levels decreased following a half‐life of about 60‐120 minutes.…”

Section: Discussionmentioning

confidence: 99%

Massive release of the histamine‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

Boehm

Reiter

Ristl

et al. 2019

Allergy

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Background Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs, and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin‐sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans. Methods Plasma DAO, tryptase, and histamine concentrations of four severe anaphylaxis events were determined at multiple serial time points in two patients with systemic mastocytosis. The histamine degradation rates were measured in anaphylaxis samples and in pregnancy sera and plasma with comparable DAO concentrations. Results Mean DAO (132 ng/mL) and tryptase (304 ng/mL) concentrations increased 187‐ and 4.0‐fold, respectively, over baseline values (DAO 0.7 ng/mL, tryptase 76 ng/mL) during severe anaphylaxis. Under non‐anaphylaxis conditions, DAO concentrations were not elevated in 29 mastocytosis patients compared to healthy volunteers and there was no correlation between DAO and tryptase levels in mastocytosis patients. The histamine degradation rate of DAO in plasma from mastocytosis patients during anaphylaxis is severely compromised compared to DAO from pregnancy samples. Conclusion During severe anaphylaxis in mastocytosis patients, DAO is likely released from heparin‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis, DAO inhibition is essential to inhibit further histamine degradation after blood withdrawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.

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“…charge and molecular weight) between DAO-B (the main fraction of pregnancy DAO) and post-heparin DAO may be related to the great differences in the elimination rates from blood found by Hansson [2].…”

Section: G Tufvessonmentioning

confidence: 98%

A comparison between diamine oxidases from human post-heparin blood serum, pregnancy blood serum and amniotic fluid

Tufvesson¹

1978

Scandinavian Journal of Clinical and Laboratory Investigation

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Diamine oxidase (DAO) was purified from blood serum after intravenous heparin injection, from pregnancy blood serum and amniotic fluid. On DEAE-Sephadex, DAO from amniotic fluid as well as from pregnancy blood serum was separated in two active fractions with molecular weights of 245,000 and 485,000, respectively. Post-heparin blood serum contained only one active DAO fraction with a molecular weight of 185,000. The purified enzymes showed similar enzymatic properties.

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Diamine Oxidase Isoenzymes in Human Blood Plasma

Cited by 10 publications

References 10 publications

Response of Plasma Histaminase Activity to Small Doses of Heparin in Normal Subjects and Patients with Hyperlipoproteinemia

Response of Plasma Histaminase Activity to Small Doses of Heparin in Normal Subjects and Patients with Hyperlipoproteinemia

Massive release of the histamine‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

A comparison between diamine oxidases from human post-heparin blood serum, pregnancy blood serum and amniotic fluid

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