Recent approaches towards bone tissue engineering

Maia, F. Raquel; Bastos, Ana Raquel; Oliveira, Joaquím M.; Correlo, Vítor M.; Reis, Rui L.

doi:10.1016/j.bone.2021.116256

Cited by 61 publications

(35 citation statements)

References 191 publications

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“…The ideal material destined for bone tissue engineering should exhibit certain properties: mechanical characteristics analogous to bone tissues, the ability to support the proliferation and differentiation of cells, the tendency to establish the deposition of the extracellular matrix [ 197 ], biocompatibility to support cellular interactions and tissue growth, biodegradability, absorbability, and last but not least, innocuity. Cumulative properties such as crystallinity and purity, in comparison to commonly used materials, promote bacterial cellulose as a superior qualitative medical material [ 198 ].…”

Section: Bacterial Cellulose Composites—important Emerging Materials ...mentioning

confidence: 99%

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

et al. 2022

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Nowadays, the development of new eco-friendly and biocompatible materials using ‘green’ technologies represents a significant challenge for the biomedical and pharmaceutical fields to reduce the destructive actions of scientific research on the human body and the environment. Thus, bacterial cellulose (BC) has a central place among these novel tailored biomaterials. BC is a non-pathogenic bacteria-produced polysaccharide with a 3D nanofibrous structure, chemically identical to plant cellulose, but exhibiting greater purity and crystallinity. Bacterial cellulose possesses excellent physicochemical and mechanical properties, adequate capacity to absorb a large quantity of water, non-toxicity, chemical inertness, biocompatibility, biodegradability, proper capacity to form films and to stabilize emulsions, high porosity, and a large surface area. Due to its suitable characteristics, this ecological material can combine with multiple polymers and diverse bioactive agents to develop new materials and composites. Bacterial cellulose alone, and with its mixtures, exhibits numerous applications, including in the food and electronic industries and in the biotechnological and biomedical areas (such as in wound dressing, tissue engineering, dental implants, drug delivery systems, and cell culture). This review presents an overview of the main properties and uses of bacterial cellulose and the latest promising future applications, such as in biological diagnosis, biosensors, personalized regenerative medicine, and nerve and ocular tissue engineering.

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Section: Bacterial Cellulose Composites—important Emerging Materials ...mentioning

confidence: 99%

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

et al. 2022

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“…Bone tissue engineering (BTE) is a field that strives to outperform current treatments by providing potential alternatives to overcome the limitations of current approaches in bone regeneration [ 7 ]. Bone tissue engineering aims to induce new tissue repair and regeneration by the synergy of reparative cells, signalling molecules and scaffolds.…”

Section: Introductionmentioning

confidence: 99%

“…Crucially, vascularisation must occur alongside bone formation to support the needs of the growing tissue [ 8 , 9 ]. Many strategies have been explored towards enhancing the osteogenic and angiogenic capacity of scaffolds [ 7 , 8 ] with structural hallmarks close to the nanoscale composition of natural bone and modifications to enhance physicochemical interactions, biocompatibility, mechanical stability and cellular attachment/survival. While bone tissue engineering has provided promising results, it has become increasingly clear that the hierarchical integration of bone scaffolds and vascular networks to create constructs that support both osteogenic and angiogenic growth is crucial for success.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticles in Bone Tissue Engineering

2022

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Large bone defects with limited intrinsic regenerative potential represent a major surgical challenge and are associated with a high socio-economic burden and severe reduction in the quality of life. Tissue engineering approaches offer the possibility to induce new functional bone regeneration, with the biomimetic scaffold serving as a bridge to create a microenvironment that enables a regenerative niche at the site of damage. Magnetic nanoparticles have emerged as a potential tool in bone tissue engineering that leverages the inherent magnetism of magnetic nano particles in cellular microenvironments providing direction in enhancing the osteoinductive, osteoconductive and angiogenic properties in the design of scaffolds. There are conflicting opinions and reports on the role of MNPs on these scaffolds, such as the true role of magnetism, the application of external magnetic fields in combination with MNPs, remote delivery of biomechanical stimuli in-vivo and magnetically controlled cell retention or bioactive agent delivery in promoting osteogenesis and angiogenesis. In this review, we focus on the role of magnetic nanoparticles for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease. We highlight the materials-design pathway from implementation strategy through the selection of materials and fabrication methods to evaluation. We discuss the advances in this field and unmet needs, current challenges in the development of ideal materials for bone-tissue regeneration and emerging strategies in the field.

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“…Instead, the new field of bone tissue engineering holds great potential as an alternative approach to treating large bone defects. It has, therefore, been extensively developed over the past few decades [ 3 ]. However, engineered tissue constructs remain limited for clinical applications for reasons such as a low osteogenic efficiency and an insufficient vascularization capacity [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Small Intestinal Submucosa Biomimetic Periosteum Promotes Bone Regeneration

Zeng

et al. 2022

Membranes

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Background: Critical bone defects are a significant problem in clinics. The periosteum plays a vital role in bone regeneration. A tissue-engineered periosteum (TEP) has received increasing attention as a novel strategy for bone defect repairs. Methods: In this experiment, a biomimetic periosteum was fabricated by using coaxial electrospinning technology with decellularized porcine small intestinal submucosa (SIS) as the shell and polycaprolactone (PCL) as the core. In vitro, the effects of the biomimetic periosteum on Schwann cells, vascular endothelial cells, and bone marrow mesenchymal stem cells were detected by a scratch test, an EdU, a tube-forming test, and an osteogenesis test. In vivo, we used HE staining to evaluate the effect of the biomimetic periosteum on bone regeneration. Results: In vitro experiments showed that the biomimetic periosteum could significantly promote the formation of angiogenesis, osteogenesis, and repaired Schwann cells (SCs). In vivo experiments showed that the biomimetic periosteum could promote the repair of bone defects. Conclusions: The biomimetic periosteum could simulate the structural function of the periosteum and promote bone repair. This strategy may provide a promising method for the clinical treatment of skull bone defects.

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Recent approaches towards bone tissue engineering

Cited by 61 publications

References 191 publications

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

Magnetic Nanoparticles in Bone Tissue Engineering

Small Intestinal Submucosa Biomimetic Periosteum Promotes Bone Regeneration

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