Magnetic Nanoparticles in Bone Tissue Engineering

Dasari, Akshith; Xue, Jingyi; Deb, Sanjukta

doi:10.3390/nano12050757

Cited by 35 publications

(28 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In general, the toxicity of nanoparticles depends on their physical and chemical properties, such as particle size, surface properties, and chemical composition (Huang et al, 2017b). Therefore, before evaluating the toxicity of IONPs in vitro and in vivo, their (Dasari et al, 2022)).…”

Section: Iron Oxide Nanoparticle Safetymentioning

confidence: 99%

See 1 more Smart Citation

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Wang

Xie

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds.

show abstract

Section: Iron Oxide Nanoparticle Safetymentioning

confidence: 99%

“…FIGURE 5Structure of IONPs. IONPs consist primarily of an IO core, a coating and an external modification layer (This diagram is drawn from(Dasari et al, 2022)). …”

mentioning

confidence: 99%

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Wang

Xie

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Bioactive factors used in bone tissue engineering include the following three categories: 1) growth factors, 2) genetic substances, and 3) drugs (Dasari et al, 2022). The main effect of drug delivery is to resist local inflammation, to reduce the immune response, and to provide bone nutrition in bone tissue engineering.…”

Section: Mechanism Of Mirnas In Bone Tissue Engineeringmentioning

confidence: 99%

Applications of Nonviral Biomaterials for microRNA Transfection in Bone Tissue Engineering

Zhu

Gu²,

Bian³

et al. 2022

Front. Mater.

View full text Add to dashboard Cite

Bone tissue engineering, which involves scaffolds, growth factors, and cells, has been of great interest to treat bone defects in recent years. MicroRNAs (miRNAs or miRs) are small, single-stranded, noncoding RNAs that closely monitor and regulate the signaling pathway of osteoblast differentiation. Thus, the role of miRNAs in bone tissue engineering has attracted much attention. However, there are some problems when miRNAs are directly applied in the human body, including negative charge rejection of the cell membrane, nuclease degradation, immunotoxicity, and neurotoxicity. Therefore, it is necessary to use a suitable carrier to transfect miRNAs into cells. In contrast to viral vectors, nonviral vectors are advantageous because they are less immunogenic and toxic; they can deliver miRNAs with a higher molecular weight; and they are easier to construct and modify. This article reviews the application of different miRNAs or anti-miRNAs in bone tissue engineering and the related signaling pathways when they promote osteogenic gene expression and osteogenic differentiation of target cells. An overview of the properties of different types of nonviral miRNA-transfected biomaterials, including calcium phosphates, nanosystems, liposomes, nucleic acids, silk-based biomaterials, cell-penetrating peptides, bioactive glass, PEI, and exosomes, is also provided. In addition, the evaluations in load efficiency, release efficiency, cell uptake rate, biocompatibility, stability, and biological immunity of nonviral miRNA-transfected biomaterials are given. This article also confirms that these biomaterials stably deliver miRNA to promote osteogenic gene expression, osteogenic differentiation of target cells, and mineralization of the extracellular matrix. Because there are differences in the properties of various nonviral materials, future work will focus on identifying suitable transfection materials and improving the transfection efficiency and biocompatibility of materials.

show abstract

“…The problem with the traditional contrast agents is the high leakage rate which causes the loss of emitted signal after short time course[ 29 ]. The contrast features of MNPs and their high safety profile encouraged many researchers to use them for labeling MSCs prior to injection[ 18 ]. MSCs labelled with MNPs have less leaking tendency and do not affect their stemness[ 30 ], rate of proliferation and the differentiation potential beside providing higher contrast-to-noise ratio for effective imaging[ 31 , 32 ].…”

Section: Mnps As a Contrast Agent To Track Mscsmentioning

confidence: 99%

“…Combining MNPs with stem cells was found to enhance their therapeutic performance and solve many challenges that hamper their regenerative potential and delay their clinical applications[ 17 ]. There are many types of MNPs that have been fabricated, but the most non-toxic and non- immunogenic MNPs that have been used with MSCs are iron oxide nanoparticles (IONs) such as magnetite (Fe 3 O 4 ) or its oxidized form maghemite (γ-Fe 2 O 3 )[ 18 - 20 ]. These iron oxides based MNPs can be synthesized with different particles’ diameters such as Superparamagnetic iron oxide (SPIO) nanoparticles (50–200 nm diameter)[ 21 ] and ultra-small SPIO (USPIO) nanoparticles (around 35 nm diameter)[ 22 ] and different types of stabilizing non-toxic coating substrates such as dextran, polyethylene glycol, and Silica[ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles

Abu‐El‐Rub¹,

Khasawneh²,

Almahasneh³

2022

WJSC

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cord. Huge advances have been achieved in comprehending the possible mechanisms underlying the therapeutic functions of MSCs. Despite the proven role of MSCs in repairing and healing of many disease modalities, many hurdles hinder the transferring of these cells in the clinical settings. Among the most reported problems encountering MSCs therapy in vivo are loss of tracking signal post-transplantation, insufficient migration, homing and engraftment post-infusion, and undesirable differentiation at the site of injury. Magnetic nano particles (MNPs) have been used widely for various biomedical applications. MNPs have a metallic core stabilized by an outer coating material and their ma gnetic properties can be modulated by an external magnetic field. These magnetic properties of MNPs were found to enhance the quality of diagnostic imaging procedures and can be used to create a carrying system for targeted delivery of therapeutic substances mainly drug, genes and stem cells. Several studies highlighted the advantageous outcomes of combining MSCs with MNPs in potentiating their tracking, monitoring, homing, engraftment and differentiation. In this review, we will discuss the role of MNPs in promoting the therapeutic profile of MSCs which may improve the success rate of MSCs transplantation and solve many challenges that delay their clinical applicability.

show abstract

Magnetic Nanoparticles in Bone Tissue Engineering

Cited by 35 publications

References 94 publications

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Applications of Nonviral Biomaterials for microRNA Transfection in Bone Tissue Engineering

Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles

Contact Info

Product

Resources

About