Recent Analytical Method for Detection of Chemical Adulterants in Herbal Medicine

Pratiwi, Rimadani; Dipadharma, Ratu Hanifa Fayza; Prayugo, Ishmat Jati; Layandro, Olivia Angelina

doi:10.3390/molecules26216606

Cited by 25 publications

(13 citation statements)

References 59 publications

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“…It caused primary pulmonary hypertension and valvular heart disease. This drug was withdrawn from market in 1997 [ 162 ]. In some weight control programs using an orexigens, diuretics, stimulants and laxative agents, it has been demonstrated that these products contain adulterants as ephedrine, norephedrine, caffeine and furosemide [ 163 ].…”

Section: Safety and Quality Control Of Nutraceuticalsmentioning

confidence: 99%

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A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

et al. 2022

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Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that are biologically active and possess capability for maintaining optimal health and benefits. These products play a significant role in human health care and its endurance, most importantly for the future therapeutic development. Nutraceuticals have received recognition due to their nutritional benefits along with therapeutic effects and safety profile. Nutraceuticals are globally growing in the field of services such as health care promotion, disease reduction, etc. Various drug nutraceutical interactions have also been elaborated with various examples in this review. Several patents on nutraceuticals in agricultural applications and in various diseases have been stated in the last section of review, which confirms the exponential growth of nutraceuticals’ market value. Nutraceuticals have been used not only for nutrition but also as a support therapy for the prevention and treatment of various diseases, such as to reduce side effects of cancer chemotherapy and radiotherapy. Diverse novel nanoformulation approaches tend to overcome challenges involved in formulation development of nutraceuticals. Prior information on various interactions with drugs may help in preventing any deleterious effects of nutraceuticals products. Nanotechnology also leads to the generation of micronized dietary products and other nutraceutical supplements with improved health benefits. In this review article, the latest key findings (clinical studies) on nutraceuticals that show the therapeutic action of nutraceutical’s bioactive molecules on various diseases have also been discussed.

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Section: Safety and Quality Control Of Nutraceuticalsmentioning

confidence: 99%

“…It caused primary pulmonary hypertension and valvular heart disease. This drug was withdrawn from market in 1997 [ 162 ].…”

Section: Safety and Quality Control Of Nutraceuticalsmentioning

confidence: 99%

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

et al. 2022

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“…Several analytical methods such as high‐performance liquid chromatography (HPLC), LC‐mass spectrometry (LC‐MS), thin layer chromatography‐surface enhanced Raman spectroscopy (TLC‐SERS), and near‐infrared spectroscopy have been used to screen adulteration in herbal products [15]. Still, very few methods, including LC‐MS [16], TLC‐SERS [14], and high‐performance TLC (HPTLC)‐bioluminescent bioautography [17] are available to detect hypolipidemics in herbal supplements.…”

Section: Introductionmentioning

confidence: 99%

Detection of synthetic lipid‐lowering adulterants in herbal products using high‐performance thin‐layer chromatography

Joshi,

Bahliwala,

Vadalia

et al. 2023

Separation Science Plus

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Adulterating herbal medicine with undeclared synthetic drugs is a worldwide problem that seriously threatens human health. To detect such illicit and not labeled synthetic hypolipidemic substances in herbal medicines, an analytical method to simultaneously identify and quantify atorvastatin (ATV) calcium, simvastatin (SIM), gemfibrozil (GEM), fenofibrate (FEN) belonging to two different classes of drugs (statins and fibrates) was developed based on high‐performance thin‐layer chromatography. The method consisted of Silica Gel G60 F254 precoated aluminum plate as stationary phase and toluene: ethyl acetate: formic acid (7:3:0.3, v/v/v) as optimized mobile phase. The densitometric evaluation wavelength was optimized at 254 nm. The Rf values of ATV, SIM, GEM, and FEN were 0.157, 0.268, 0.691, and 0.852, respectively. The linearity range is between 100–1500 ng/band for ATV and FEN and 200–3000 ng/band for SIM and GEM, respectively. The accuracy was found to be in the range of 97%–105%. The relative standard deviation of precision and robustness was found to be < 5%. However, the five screened market samples did not show the presence of adulteration of the above drugs. This method for the simultaneous determination of four drugs may be successfully employed to screen synthetic hypolipidemics as adulterants in herbal products and dietary supplements.

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“…Therefore, there are some accidental or intentional contaminations and adulteration with nonmedicinal plants or other undesirable plant tissues [14,15]. Such contamination could reduce the effectiveness of the active ingredients, which might lead to detrimental health consequences [16,17]. The authentication of plant material has become necessary for safe use, avoiding adulteration, and trade in medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

DNA Barcodes for Accurate Identification of Selected Medicinal Plants (Caryophyllales): Toward Barcoding Flowering Plants of the United Arab Emirates

et al. 2022

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The need for herbal medicinal plants is steadily increasing. Hence, the accurate identification of plant material has become vital for safe usage, avoiding adulteration, and medicinal plant trading. DNA barcoding has shown to be a valuable molecular identification tool for medicinal plants, ensuring the safety and efficacy of plant materials of therapeutic significance. Using morphological characters in genera with closely related species, species delimitation is often difficult. Here, we evaluated the capability of the nuclear barcode ITS2 and plastid DNA barcodes rbcL and matK to identify 20 medicinally important plant species of Caryophyllales. In our analysis, we applied an integrative approach for species discrimination using pairwise distance-based unsupervised operational taxonomic unit “OTU picking” methods, viz., ABGD (Automated Barcode Gap Analysis) and ASAP (Assemble Species by Automatic Partitioning). Along with the unsupervised OTU picking methods, Supervised Machine Learning methods (SML) were also implemented to recognize divergent taxa. Our results indicated that ITS2 was more successful in distinguishing between examined species, implying that it could be used to detect the contamination and adulteration of these medicinally important plants. Moreover, this study suggests that the combination of more than one method could assist in the resolution of morphologically similar or closely related taxa.

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Recent Analytical Method for Detection of Chemical Adulterants in Herbal Medicine

Cited by 25 publications

References 59 publications

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

Detection of synthetic lipid‐lowering adulterants in herbal products using high‐performance thin‐layer chromatography

DNA Barcodes for Accurate Identification of Selected Medicinal Plants (Caryophyllales): Toward Barcoding Flowering Plants of the United Arab Emirates

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