Recent Advances on Quinoxaline-Based Photoinitiators of Polymerization

Dumur, Frédéric

doi:10.3390/catal13040718

Cited by 2 publications

(1 citation statement)

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“…It is a low-melting solid (29-30 • C), soluble in water, and a weak base (pKa = 0.56) [15]. Several studies were performed and displayed a wide range of pharmacological activities for quinoxaline derivatives (Figure 1) [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Additionally, quinoxalines are used for crop protection as a component of insecticides, herbicides, and fungicides [31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

Zayed

2023

Chemistry

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Quinoxaline is a fused heterocycle system of a benzene ring and pyrazine ring. It has earned considerable attention due to its importance in the field of medicinal chemistry. The system is of extensive importance due to its comprehensive array of biological activities. Quinoxaline derivatives have been used as anticancer, anticonvulsant, anti-inflammatory, antidiabetic, antioxidant, antibacterial, anti-TB, antimalarial, antiviral, anti-HIV, and many other uses. Variously substituted quinoxalines are significant therapeutic agents in the pharmaceutical industry. This review spotlights on the chemistry, physiochemical characters, synthesis, pharmaceutical products, and medicinal chemistry of various anticancer quinoxaline derivatives that were developed in the last period. It covers the period from 2016 to 2023.

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Section: Introductionmentioning

confidence: 99%

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

Zayed

2023

Chemistry

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A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

2023

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In last few decades, nitrogen‐containing heterocycles have maintained their status as an important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is one such class of nitrogen‐containing scaffold that has become a subject of extensive research as it possess a plethora of biological activities. Molecular hybridization is a versatile and rational approach to drug design that involves the combination of two bioactive molecules possessing distinct intrinsic activity into a single scaffold for enhancing their therapeutic potential. In view of this, the advancement and potential of quinoxaline hybrids bearing thiazole, triazole, oxadiazole, pyrrolizines, pyrazole, etc. have attracted the keen attention of researchers to explore their therapeutic ability against different biological targets. The present review includes the research in the recent years (2018–2023) and addresses the graceful advancements in the studies related to quinoxaline‐based small molecules including their synthetic routes, biological activities and structure‐activity relationships. We anticipate that this review article will provide comprehensive knowledge of pharmacological importance of quinoxaline analogues and will fulfill the need of scientific community in designing and developing efficacious novel molecules.

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Recent Advances on Quinoxaline-Based Photoinitiators of Polymerization

Cited by 2 publications

References 251 publications

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

Chemistry, Synthesis, and Structure Activity Relationship of Anticancer Quinoxalines

A Review on Multipurpose Potential of Bioactive Heterocycle Quinoxaline

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