Recent advances on biomedical applications of pectin-containing biomaterials

Eivazzadeh‐Keihan, Reza; Noruzi, Ehsan Bahojb; Aliabadi, Hooman Aghamirza Moghim; Sheikhaleslami, Sahra; Akbarzadeh, Ali Reza; Hashemi, Seyed Masoud; Gorab, Mostafa Ghafori; Maleki, Ali; Cohan, Reza Ahangari; Mahdavi, Mohammad; Poodat, Roksana; Keyvanlou, Faeze; Esmaeili, Mir Saeed

doi:10.1016/j.ijbiomac.2022.07.016

Cited by 41 publications

(27 citation statements)

References 167 publications

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“…A wound dressing is a bandage used to cover a wound and help it heal by attaching it to the surrounding cellular tissue or bandaging the wound. This can be in the form of hydrogels [20][21][22][23][24][25] foam, 26 etc. The use of materials that are biocompatible and non-toxic to living cells, together with the ability to reduce the wound healing time, has been considered by many researchers.…”

Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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Section: Biological Properties and Wound Dressing Applications Of Car...mentioning

confidence: 99%

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

et al. 2022

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“…Pec possesses a higher range of heterogeneity in their structure due to their sources and methods of different extraction process [ 22 ]. Pec is considered as a promising candidate in the drug delivery field due to its excellent features such as non-toxicity, biocompatibility, biodegradability, low-cost, antibacterial, and anti-inflammatory properties [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…To our best of knowledge, recently there have been no reviews published specifically focusing on “Pec based hydrogel for drug delivery systems”. However, there are two general reviews on Pec based biomaterials for biomedical applications [ 23 , 24 ]. Thus, this is a sole mini review where we tried to compile the latest progress and advances specifically on Pec based hydrogels for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Pectin Based Hydrogels for Drug Delivery Applications: A Mini Review

Han

Park

et al. 2022

Gels

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Over the past few decades, hydrogel systems using natural polymers have been expansively employed in drug delivery applications. Among the various reported biopolymer-based hydrogel drug delivery systems, pectin (Pec) is an exceptional natural polymer due to its unique functionalities and excellent properties such as biocompatibility, biodegradability, low-cost, and simple gelling capability, which has received considerable interest in the drug delivery fields. Since there is an increasing need for biomaterials with unique properties for drug delivery applications, in this review, hydrogels fabricated from natural pectin polymers were thoroughly investigated. Additionally, the present mini review aims to bring collectively more concise ways such as sources, extraction, properties, and various forms of Pec based hydrogel drug delivery systems and their toxicity concerns are summarized. Finally, the potential objectives and challenges based on pectin-based hydrogel drug delivery systems are also discussed.

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“…The uncomplicated release of drug molecules at high pH, antibacterial activity, and maintenance of an acidic environment are among the advantages of biomaterials based on the three-dimensional structure formed by LMP and cation bridges for wound healing. Their cytocompatibility regarding different types cells and the tunable mechanical properties of pectin gels contribute to their application as tissue engineering scaffolds [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…In general, pectin-containing scaffolds are biocompatible [ 7 , 18 ]. However, the biocompatibility of pectin gels formed by different cross-linking cations has not been compared yet.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cross-Linking Cations on In Vitro Biocompatibility of Apple Pectin Gel Beads

Popov

Paderin

Chistiakova

et al. 2022

IJMS

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The study aimed to compare the in vitro biocompatibility of pectin gels formed by different cross-linking cations. Hydrogel beads named CaPG, ZnPG, FePG, and AlPG were prepared from 4% solutions of apple pectin using ionotropic gelling with CaCl2, ZnCl2, FeCl3, and AlCl3, respectively. Cations influenced the gel strength of the wet gel beads in the following order (least strong) Ca2+ < Zn2+ < Fe3+~Al3+ (most strong). The swelling degree of the CaPG beads after 24 h of incubation in the RPMI-1640 medium was 104%, whereas the ZnPG, FePG, and AlPG beads swelled by 76, 108, and 134%, respectively. The strength of the pectin gel decreased significantly after incubation in the RPMI-1640 medium for 24 h, regardless of the cross-linking cation, although the FePG beads remained the strongest. All the pectin beads adsorbed serum proteins to a low degree, however the serum protein adsorption by the ZnPG and FePG beads (1.46 ± 0.87 and 1.35 ± 0.19 µg/mm2) was more than the CaPG and AlPG beads (0.31 ± 0.36 and 0.44 ± 0.25 µg/mm2). All the pectin beads reduced the production of TNF-α and IL-10 by hPBMCs in response to LPS stimulation. The IL-1β response of cells to LPS was significantly reduced by the CaPG, ZnPG, and FePG beads, whereas the AlPG beads enhanced it twofold. The CaPG, FePG, and AlPG beads had no cytotoxicity. The viability of hPBMCs and human fibroblasts incubated with ZnPG beads was 5.3 and 7.2%, respectively. Thus, the use of different cross-linking cations changed the properties of the pectin gel, which is important for biocompatibility.

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Recent advances on biomedical applications of pectin-containing biomaterials

Cited by 41 publications

References 167 publications

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

Pectin Based Hydrogels for Drug Delivery Applications: A Mini Review

Effect of Cross-Linking Cations on In Vitro Biocompatibility of Apple Pectin Gel Beads

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