Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed.
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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).
The combination of
multiple physiological (swelling, porosity,
mechanical, and biodegradation) and biological (cell/tissue-adhesive,
cell proliferation, and hemostatic) properties on a single hydrogel
has great potential for skin tissue engineering. Adhesive hydrogels
based on polydopamine (PDA) have become the most popular in the biomedical
field; however, integrating multiple properties on a single adhesive
hydrogel remains a challenge. Here, inspired by the chemistry of mussels,
we developed PDA–sodium alginate–polyacrylamide (PDA–SA–PAM)-based
hydrogels with multiple physiological and biological properties for
skin tissue engineering applications. The hydrogels were prepared
by alkali-induced polymerization of DA followed by complexation with
SA in PAM networks. The chemical composition of the hydrogels was
characterized by X-ray photoelectron spectroscopy. PDA–SA complexed
chains were homogeneously dispersed in the PAM network and exhibited
good elasticity and excellent mechanical properties, such as a compressive
stress of 0.24 MPa at a compression strain of 70% for 0.4PDA–SA–PAM.
The adhesive hydrogel also maintained a highly interconnected porous
structure (∼94% porosity) along with PDA microfibrils. The
hydrogel possesses outstanding swelling and biodegradability properties.
Owing to the presence of the PDA–SA complex in the PAM network,
the hydrogels show good adhesion to various substrates (plastic, skin,
glass, computer screens, and leaves); for example, the adhesive strength
of the 0.4PDA–SA–PAM to porcine skin was 24.5 kPa. The
adhesive component of the PDA–SA chains in the PAM network
significantly improves the cell proliferation, cell attachment, cell
spreading, and functional expression of human skin fibroblasts (CCD-986sk)
and keratinocytes. Moreover, the PDA chains exhibited good hemostatic
properties, resulting in rapid blood coagulation. Considering their
excellent cell affinity, and rapid blood coagulation ability, these
mussel-inspired hydrogels have substantial potential for skin tissue
engineering applications.
To develop a gentamicin-loaded wound dressing, cross-linked hydrogel films were prepared with polyvinyl alcohol (PVA) and dextran using the freezing-thawing method. Their gel properties such as gel fraction, swelling, water vapor transmission test, morphology, tensile strength, and thermal property were investigated. In vitro protein adsorption test, in vivo wound healing test, and histopathology were performed. Dextran decreased the gel fraction, maximum strength, and thermal stability of hydrogels. However, it increased the swelling ability, water vapor transmission rate, elasticity, porosity, and protein adsorption. The drug gave a little positive effect on the gel properties of hydrogels. The gentamicin-loaded wound dressing composed of 2.5% PVA, 1.13% dextran, and 0.1% drug was more swellable, flexible, and elastic than that with only PVA because of its cross-linking interaction with PVA. In particular, it could provide an adequate level of moisture and build up the exudates on the wound area. From the in vivo wound healing and histological results, this gentamicin-loaded wound dressing enhanced the healing effect more compared to conventional product because of the potential healing effect of gentamicin. Thus, this gentamicin-loaded wound dressing would be used as a potential wound dressing with excellent forming and improved healing effect in wound care.
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