Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

Bădilă, Adrian; Rădulescu, Dragoş Mihai; Niculescu, Adelina-Gabriela; Grumezescu, Alexandru Mihai; Rădulescu, Marius; Radulescu, A

doi:10.3390/cancers13164229

Cited by 49 publications

(57 citation statements)

References 182 publications

(392 reference statements)

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“…In terms of the frequency of localization of metastatic lesions, the skeleton ranks third after the lungs and liver, and the symptoms of bone lesions (especially with pathological fractures) may be the first and only manifestation of the development of a malignant tumor in the body [40,41]. With the development of bone metastases, the quality of life deteriorates: the risk of pathological fractures is high, compression of the spinal cord with the development of neurological deficit is possible, hypercalcemia develops, and severe pain syndrome appears.…”

Section: Discussionmentioning

confidence: 99%

Monitoring and personalization in treatment of breast cancer patients with metastatic bone lesions

et al. 2022

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The aim. To increase the efficiency of treatment of BC patients with metastatic lesions of long tubular bones by using, Multidetector computed tomography (MDCT) and bone marrow markers for diagnostics and monitoring the clinical course of the oncologic process, accompanied by surgical intervention with endoprosthetics along with the treatment of polymorbid pathology in a specific patient. Materials and methods. Authors provide systemic personification including visualization of the tumor site and its vascularization; printing out the 3D model; surgical planning, including optimal surgical access to the tumor site considering the volume and topographic and anatomical location and dissemination of the tumor, the convenience of intraoperative tasks (removal of the tumor, bone grafting or endoprosthetics), preoperative planning of bone resection lines with maximum preservation of intact bone tissue. Results. Personalization of the treatment of breast cancer patients with metastatic bone lesions contributes to a significant reduction in postoperative complications of endoprosthetic replacement of large joints (up to 15.2 %) and increases the overall three-year survival rate (up to 40.6 %), as well as significantly improves their quality of life. Conclusions. The personalization of treatment of patients with tumor lesions of the skeletons contributes to a significant decrease in the indicator of postoperative complications of endoprosthetics of great joints and to an increase in the total three-year survival rate, as well as to the improvement of the quality of life after the conducted treatment.

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Section: Discussionmentioning

confidence: 99%

Monitoring and personalization in treatment of breast cancer patients with metastatic bone lesions

et al. 2022

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“…Secondary bone cancers occur due to various other advanced cancers in the body which spreads to the bones (Fan et al., 2019 ). The following section describes various types of these cancers to have a deeper understanding of the differences among them (Bădilă et al., 2021 ).…”

Section: Bone Cancer Typesmentioning

confidence: 99%

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Shao

Wang

et al. 2022

Drug Delivery

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Primary bone tumors especially, sarcomas affect adolescents the most because it originates from osteoblasts cells responsible for bone growth. Chemotherapy, surgery, and radiation therapy are the most often used clinical treatments. Regrettably, surgical resection frequently fails to entirely eradicate the tumor, which is the primary cause of metastasis and postoperative recurrence, leading to a high death rate. Additionally, bone tumors frequently penetrate significant regions of bone, rendering them incapable of self-repair, and impairing patients' quality of life. As a result, treating bone tumors and regenerating bone in the clinic is difficult. In recent decades, numerous sorts of alternative therapy approaches have been investigated due to a lack of approved treatments. Among the novel therapeutic approaches, hydrogel-based anticancer therapy has cleared the way for the development of new targeted techniques for treating bone cancer and bone regeneration. They include strategies such as co-delivery of several drug payloads, enhancing their biodistribution and transport capabilities, normalizing accumulation, and optimizing drug release profiles to decrease the limitations of current therapy. This review discusses current advances in functionalized hydrogels to develop a new technique for treating bone tumors by reducing postoperative tumor recurrence and promoting tissue repair.

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“…Chemotherapeutic drugs can be employed in the treatment of cancer patients, as they interfere with the cell cycle and the process of mitosis, causing a greater proportion of cell kill in tumor cells than in healthy tissues [206]. Nonetheless, large systemic doses of such aggressive drugs may lead to drug resistance and adverse effects, while their repeated administration requires a strict treatment schedule that must be adapted to the ability of healthy tissues to recover [207][208][209]. Thus, attention has been drawn to developing carrier systems that allow a controlled release at the tumor site.…”

Section: Drug Deliverymentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

Cited by 49 publications

References 182 publications

Monitoring and personalization in treatment of breast cancer patients with metastatic bone lesions

Monitoring and personalization in treatment of breast cancer patients with metastatic bone lesions

Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations

Polymer-Based Nanosystems—A Versatile Delivery Approach

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