Recent advances in the synthetic and medicinal perspective of quinolones: A review

Dhiman, Prashant; Arora, Nidhi; Veeraveedu, Punniyakoti T.; Monga, Vikramdeep

doi:10.1016/j.bioorg.2019.103291

Cited by 107 publications

(55 citation statements)

References 172 publications

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“…The most important properties of lanthanides result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. The strong electropositive character of lanthanides decreases with the drop in radius size, europium being the most reactive; likewise, the strong ionic trait of the compounds and the basic character of the hydroxides drop along the series, Yb(OH) 3 and Lu(OH) 3 being the least basic of all. Consequently, their aqua ions are the most predisposed to hydrolysis, phenomena that can be prevented by working in acidic conditions [34,35].…”

Section: Metal Complexes Of Quinolones With Lanthanide Ionsmentioning

confidence: 99%

“…The luminescence quenching effect of the phosphate anion on the Tb 3+ -4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid-ethyl- [1,3,4]thiadiazol-2-yl) amide was used in order to determine the former. The system was analyzed in aqueous solution, at a pH value of 7.4, using λ ex = 320 nm and λ em = 548 nm.…”

Section: Quantitative Determination Of Lanthanide and Miscellaneous Ionsmentioning

confidence: 99%

“…Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability [1,2], characteristics that make them suitable candidates for treating infectious diseases with various localizations: cutaneous, urinary, respiratory, bone, gastrointestinal, etc. [3].…”

Section: Introductionmentioning

confidence: 99%

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Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

2020

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Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here.

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Section: Metal Complexes Of Quinolones With Lanthanide Ionsmentioning

confidence: 99%

Section: Quantitative Determination Of Lanthanide and Miscellaneous Ionsmentioning

confidence: 99%

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Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

2020

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“…[ 170–173 ] Moreover, tens of quinoline/quinolone/quinazoline/quinazolinone‐based antibacterial agents, which are exemplified by norfloxacin, ciprofloxacin, ofloxacin, and moxifloxacin, have been used for the treatment of various bacterial infections. [ 174,175 ] Thus, indole/isatin–quinoline/quinolone/quinazoline/quinazolinone hybrids can be considered as potential candidates to discover novel inhibitors to combat both drug‐sensitive and ‐resistant organisms.…”

Section: Indole/isatin–quinoline/quinolone/quinazoline/quinazolinone mentioning

confidence: 99%

Indole/isatin‐containing hybrids as potential antibacterial agents

Song

Bian

et al. 2020

Archiv der Pharmazie

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The emergence and worldwide spread of drug-resistant bacteria have already posed a serious threat to human life, creating the urgent need to develop potent and novel antibacterial drug candidates with high efficacy. Indole and isatin (indole-2,3-dione) present a wide structural and mechanistic diversity, so their derivatives possess various pharmacological properties and occupy a salient place in the development of new drugs. Indole/isatin-containing hybrids, which demonstrate a promising activity against a panel of clinically important Gram-positive and Gram-negative bacteria, are privileged scaffolds for the discovery of novel antibacterial candidates. This review, covering articles published between January 2015 and May 2020, focuses on the development and structure-activity relationship (SAR) of indole/isatincontaining hybrids with potential application for fighting bacterial infections, to facilitate further rational design of novel drug candidates.

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“…Currently, quinolones, which are a group of antibiotics classified into four generations with expanded activity for Gram-negative organisms as Gram-positive organisms 10 , are the third most prescribed antimicrobial drugs, followed by macrolides and beta-lactams for the treatment of various pathogenic infections 11 . Most cases of community-acquired UTI are treated empirically with quinolones without knowing the isolate’s pattern of drug susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Quinolone resistance in different uropathogens isolated from urine cultures in patients with urinary tract infection

Villegas

Carrillo

Contreras

et al. 2020

Preprint

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ObjectiveTo identify patterns of resistance against quinolones in various uropathogens in urinary tract infections in the population of the Toluca valley, MexicoIntroductionQuinolones are antibiotics with a spectrum of activity for both gram-positives and gram-negatives and are antibiotics used for the empirical treatment of urinary tract infections. Recently, a high index of resistance to quinolones has been reported due to different mechanisms on the part of bacteria, however the one that has taken the greatest importance is the presence of extended spectrum beta-lactamasesMethods155 samples were collected from patients with suspected urinary tract infection without exclusion criteria such as age or gender. Automated equipment was used for the identification of the etiological agent and sensitivity tests to quinolones.ResultsThe results positives were divided to evaluate which of the two antibiotics studied had greater resistance. For ciprofloxacin there are 27 resistant strains 37%, 1 strain with intermediate resistance 1% and 45 susceptible strains 62%. For levofloxacin 26 strains are resistant 36%, 41 strains are sensitive 56% and 6 strains show intermediate sensitivity 8%.ConclusionDifferent microorganisms, both gram-positive and gram-negative, were isolated and it can be observed that gram-negative strains are the ones with the greatest resistance against quinolones, mainly Escherichia coli, which produces extended-spectrum beta-lactamases, in the case of gram-positive resistance patterns are variable with a tendency towards sensitivity.

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Recent advances in the synthetic and medicinal perspective of quinolones: A review

Cited by 107 publications

References 172 publications

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity

Indole/isatin‐containing hybrids as potential antibacterial agents

Quinolone resistance in different uropathogens isolated from urine cultures in patients with urinary tract infection

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