Recent advances in the synthesis of smart hydrogels

Sikdar, Partha; Uddin, Md Mazbah; Dip, Tanvir Mahady; Islam, Shayla; Hoque, Md. Saiful; Dhar, Avik Kumar; Wu, Shuangyan

doi:10.1039/d1ma00193k

Cited by 110 publications

(79 citation statements)

References 409 publications

(412 reference statements)

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“…Hydrogels can be synthesized using natural polymers and synthetic polymers [15]. Natural polymers are polymers that have several superior properties such as being biocompatible, biodegradable, and easily recognizable biologically.…”

Section: Introductionmentioning

confidence: 99%

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Asy-Syifa

Kusjuriansah

Waresindo

et al. 2022

J. Phys.: Conf. Ser.

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Hydrogel is composed of a three-dimensional network of hydrophilic polymers and can swell when placed in an aqueous media. Polyvinyl alcohol (PVA) is a common polymer used to produce hydrogels because it has biocompatibility, non-toxicity, chemical stability, low cost, and excellent mechanical strength. In this study, the PVA solutions were prepared with concentrations of 6%, 8%, 10%, and 12% in distilled water. The precursor solutions underwent a freeze-thaw cycle with a freezing temperature of -25 °C for 20 hours and a thawing temperature of 37 °C for 4 hours and carried out for 6 cycles. The swelling degree and the gel fraction of the hydrogel were then determined. From the swelling degree results, the increase of the PVA concentration in the precursor solutions reduced the swelling degree of the hydrogel. Based on the gel fraction test, it was revealed that all PVA concentrations have approximately the same value of gel fraction at 97%. Additionally, the viscosity and the density were also measured. Both showed an increasing trend with the addition of PVA concentration, where the viscosity values from the smallest to highest concentrations were 12.4944, 34.1737, 93.8491, and 216.2979 cP while the density values were 0.9865, 0.9871, 0.9878, and 0.9885 gram.cm-3.

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Section: Introductionmentioning

confidence: 99%

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Asy-Syifa

Kusjuriansah

Waresindo

et al. 2022

J. Phys.: Conf. Ser.

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“…The strategies for achieving the self-healing characteristics and formulating smart materials for diverse applications are continuously developed; some challenges and future outlooks were discussed recently in comprehensive reviews [ 14 , 27 , 42 , 43 , 69 , 70 , 71 , 72 , 73 ]. The present paper joins the recent efforts undertaken to design self-healing hydrogels and hybrid materials [ 6 , 7 , 14 , 27 , 29 , 30 , 31 , 37 , 53 , 74 ] with unique and targeted properties, based on synergism, by using accessible methods, without altering the functionality and structural integrity of the components.…”

Section: Resultsmentioning

confidence: 99%

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels

Bercea¹

2021

Polymers

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The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications.

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“…It is also anticipated that more research into so-called smart natural hydrogel-based bio-inks incorporating responsive moieties that facilitate responses to different environmental conditions such as pH, electric field, magnetic field, etc., will be undertaken [ 429 ]. The development of such smart bio-inks may provide a pathway for inducing transitional changes within the cell-laden matrix, thus enhancing utility in tissue engineering and sustained drug release [ 429 , 430 ]. This is because external factors such as injury and disease can lead to changes in the fabricated constructs from natural hydrogel-based bio-inks and therefore enable a targeted and time-dependent response [ 387 ].…”

Section: Future Trends and Conclusionmentioning

confidence: 99%

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

122

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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

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Recent advances in the synthesis of smart hydrogels

Abstract: Understanding the surrounding atmosphere and reacting accordingly with the precise decision are always fascinating features of a material. Materials that pose such responsiveness are called smart materials. Nowadays, research studies...

Cited by 110 publications

References 409 publications

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

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