Recent advances in the synthesis, biological activities and various applications of ferrocene derivatives

Abstract

Ferrocene derivatives constitute an important class of organometallic compounds with not only an extensive range of biological activities but also diverse industrial as well as material science applications. These stimulating features of ferrocene derivatives spurred us to review the recent advances in synthesis methods and biological and other applications reported in the latest literature. An effort has been made to summarize the recent developments in synthetic methods providing access to ferrocene scaffolds and the useful medicinal and material applications, including agricultural, catalytic, polymer, conducting, redox mediating, ferrocenyl stationary phase, rocket propellant and ion sensing applications. Ferrocene‐based bulky metallocenes are also discussed.

Ferrocenylmethylnucleobases Synthesis, DFT Calculations, Electrochemical and Spectroscopic Characterization

“…In the recent years, ferrocene derivatives chemistry has developed as a rapidly growing and maturing filed which links classical organic chemistry to organometallic chemistry [1,2]. The stability of the ferrocenyl group of ferrocene derivatives in aqueous solutions, the ease of the synthesis of a large variety of ferrocene derivatives, and its excellent electrochemical properties have made ferrocene derivatives very interesting molecules for biological applications and medicinal chemistry [3,4]. The chemistry of ferrocenylmethylnucleobases (FcMeNb) [5][6][7][8][9] is still, however, an undeveloped area compared with well-established classical medicinal chemistry of purely organic nucleobase derivatives [10][11][12][13][14][15][16][17].…”

Adsorption mechanism of ferrocene molecule on pristine and functionalized graphene

“…The compound was discovered unintentionally and simultaneously by two groups Kealy and Pauson [1] and Miller et al [2] in 1951. Ferrocene and its derivatives due to their peculiar structural, electrical, magnetic, and transport properties are [3,4] widely used in adhesion processes, catalysis, sensors, solar energy generation, hydrogen storage, cancer therapy, and nanomagnetism [5][6][7][8]. For instance, due to its π-electron system, it is getting keen interest from the researchers.…”

Enantioselective deprotometalation of N,N-dialkyl ferrocenecarboxamides using metal amides

“…Ferrocene-containing compounds have been used in different fields such as catalysis, material sciences and medicinal chemistry; thus, many efforts have been devoted to the development of efficient syntheses to produce these important substrates. 1 Among the existing ways to achieve ferrocene C-H bond functionalization, transition metal-catalyzed reactions have recently emerged, [2][3] with possible extensions to enantioselective versions. 4 However, the most efficient methods imply the use of expensive catalytic sources (e.g.…”