Recent advances in the direct transformation of propargylic alcohols to allenes

Abstract

Allenes are the simplest class of cumulenes, possessing unique physical and chemical properties. These structural units are widely used as valuable synthetic intermediates in organic synthesis, as well as the...

Recent approaches for the synthesis of pyridines and (iso)quinolines using propargylic Alcohols

“…In recent years, many review articles have appeared describing the general reactivity of propargylic alcohols for the construction of various cyclic systems, including heterocyles. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] To the best of our knowledge, no focused reviews have appeared on the synthesis of six-membered nitrogen basedheterocyclic compounds by employing the propargylic alcohols as one of the key reactants. Thus, in this review article, we aimed to summarize various approaches to N-heterocyclic compounds from propargylic alcohols, and we have limited our focus to the pyridines, quinolines, and isoquinolines.…”

“…In recent years, many review articles have appeared describing the general reactivity of propargylic alcohols for the construction of various cyclic systems, including heterocyles. 11–24…”

Recent advances in the cascade reactions of enynols/diynols for the synthesis of carbo- and heterocycles

“…In the last few decades, the cascade reactions of enynols/diynols have emerged as powerful tools for the construction of structurally diverse scaffolds with unique multifunctional properties, giving them important roles in synthetic chemistry. Compared to simple propargylic alcohols 6 and enynes/diynes, 7 enynols/diynols exhibit different reactivities, allowing them to complete a variety of transformations and functionalizations. Generally, it is easy to construct various important frameworks through Lewis or Brønsted acid-catalyzed/mediated cascade cyclization processes of enynols/diynols, resulting in significant achievements in this field.…”

Temperature controlled di- and monosulfonylation of propargyl alcohols with sodium sulfinates: switchable access to (E)-allyl, vinyldisulfones and propargyl sulfones

“…allyl, vinyldisulfones, remain almost unexplored. Thus, propargyl alcohols, which are a class of readily available and synthetically versatile multifunctional building blocks in organic chemistry, 9,10 would be a type of promising starting material to achieve molecular complexes containing the propargyl sulfone, vinyl sulfone and allyl sulfone moieties. However, to the best of our knowledge, the only example employing propargyl alcohols was reported by Loh and coworkers, where sulfinic acids were utilized as the sulfonyl reagents to deliver a series of propargyl sulfones (Fig.…”