Recent approaches for the synthesis of pyridines and (iso)quinolines using propargylic Alcohols

Abstract

Propargylic alcohols are one of the readily available and highly explored building blocks in organic synthesis. They show distinct reactivities compared to simple alcohols and/or alkynes, and hence provide diverse...

Base-catalyzed addition of silylacetylenes to ketones: a route to protected tertiary propargyl alcohols

“…Propargyl alcohols are ubiquitous building blocks in chemical synthesis, being highly valued for their widespread application as valuable synthetic intermediates or medicinally relevant molecules themselves. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] They participate in a diverse array of transformations, owing this to their multifunctionality, and thereby being the subject of numerous studies. Protected propargyl alcohols can be accessed via well-developed stoichiometric methods, including mainly the use of a combination of propargyl alcohol, chlorosilane and organolithium reagent (Fig.…”

Recent Advances in Synthetic Routes to Azacycles

“…Several studies have succeeded in synthesizing or functionalizing azacycle compounds. In addition, several methods of synthesis for aromatic azacycles have been reported [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. However, these methods still have several drawbacks such as being time-consuming, requiring a high temperature, expensive additives, and/or organic solvents, and/or having low chemoselectivity properties [ 61 , 62 , 63 ].…”