Recent Advances in Pyridine‐Based Organocatalysis and its Application towards Valuable Chemical Transformations

Abstract

The role of pyridine scaffolds in the field of synthetic organic and medicinal chemistry is impeccable and irreplaceable due to its wide spectrum of applications. Pyridines are well known for their usage as bases and to some extent they have been employed as ligands. In recent times, pyridine scaffolds are explored as organocatalysts to accomplish various novel chemical transformations. Here in this review, we have focused on highlighting the protocols available to accomplish wide range of chemical modulations employing different pyridine moieties as organocatalysts for various reactions such as reductive borylation, acylation, heterocyclization and additions to carbonyl derivatives. The application of organocatalysis in the fields of kinetic resolution and desymmetrization are also been presented

Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

“…Pyridine and its corresponding derivatives are unique heterocycles with worthwhile chemical and pharmaceutical importance, both in nature and synthesis plans. It has widely been used as key scaffold for design and preparation of novel drug candidate materials [20][21][22][23][24][25], supramolecular structures [26,27], polymers [28], and catalysts [29][30][31]. The essential vitamin B 6 , nicotine, redox NADP-NADPH 2 coenzymes and many other natural products possess pyridine ring in their structures so it is quite rational that pyridine-containing compounds continue to receive great synthetic attention in organic chemistry [32][33][34][35].…”

Chemistry with Schiff Bases of Pyridine Derivatives: Their Potential as Bioactive Ligands and Chemosensors

“…Pyridineborane is used as a reducing agent with improved stability and solubility over NaBH 4 (Figure 6). Crabtree catalyst and Milstein catalyst are well known organometallic catalyst used for hydrogenation and dehydrocoupling of alcohols respectively [12,13].…”

Crystal structure and Hirshfeld surface analysis of 4-(3-methoxyphenyl)-2,6-diphenylpyridine

“…Substituted pyridines are privileged scaffolds in medicinal chemistry and are versatile building blocks for the construction of natural products (Haghighijoo et al, 2020;Gujjarappa et al, 2020;Nirogi et al, 2015;De Rycke et al, 2011;Chan et al, 2010;Bora et al, 2010), Accordingly, great effort has been devoted to developing efficient approaches to these scaffolds (Guin et al, 2020;Wu et al, 2019;Pandolfi et al, 2017;Shen et al, 2015). Ketoxime acetates have been demonstrated to be exceptionally advantaged and versatile building blocks for the synthesis and derivatization of nitrogen-containing heterocycles through N-O bond cleavage (Zhang et al, 2020;Mao et al, 2019;Xie et al, 2018).…”