Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Sood, Ankur; Gupta, Aastha; Agrawal, Garima

doi:10.1016/j.carpta.2021.100067

Cited by 101 publications

(64 citation statements)

References 346 publications

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“…Polysaccharides are carbohydrates that comprise more than ten monosaccharide units which are interlinked through a glycosidic bond. Among the natural polymers, polysaccharides have unique properties such as biocompatibility, stability, safety, adhesive properties, affinity towards the specific receptors, and non-toxicity, which make them a vital candidate in the drug delivery system [ 9 ]. Polysaccharides show a substantial structural and chemical diversity and possess a variety of functional groups that support various chemical modifications, enhancing their stability, solubility, encapsulation, and target specificity.…”

Section: Polysaccharides Based Drug Carriersmentioning

confidence: 99%

“…Researchers have focused on polymeric drug delivery carriers since the 1980s to improve the therapeutic index and bioavailability of conventional drugs [ 8 ]. In the last two decades, the polymeric drug delivery system has emerged as a key player in cancer treatment [ 9 ]. Polymeric carriers can be tuned through chemical modification to target the diseased site and deliver the drug in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

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Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

et al. 2022

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Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer cells have been developed to overcome the toxicity of chemotherapeutics. Polysaccharides are non-toxic, biodegradable, hydrophilic biopolymers that can be easily modified chemically to improve the bioavailability and stability for delivering therapeutics into cancer tissues. Different polysaccharides, such as chitosan, alginates, cyclodextrin, pullulan, hyaluronic acid, dextran, guar gum, pectin, and cellulose, have been used in anti-cancer drug delivery systems. This review highlights the recent progress made in polysaccharides-based drug carriers in anti-cancer therapy.

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Section: Polysaccharides Based Drug Carriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

et al. 2022

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“…It should be highlighted that biocompatibility and biodegradability are critical factors to consider when selecting a material for biomedical applications. 119 Because polysaccharides have these qualities by nature, they are frequently used as a polymer matrix to develop novel products. Polysaccharide-based nanomaterials, unlike other nanoparticles, can breakdown into harmless byproducts under biological circumstances, followed by renal clearance.…”

Section: Polysaccharide-based Polymersmentioning

confidence: 99%

Selection of natural biomaterials for micro‐tissue and organ‐on‐chip models

Çeçen

Bal‐Öztürk

Yaşayan

et al. 2022

J Biomedical Materials Res

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The desired organ in micro-tissue models of organ-on-a-chip (OoC) devices dictates the optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble biological tissues' biological functions and architectures by constructing bioactivity of macromolecules, cells, nanoparticles, and other biological agents. The inclusion of such components in OoCs allows them having biological processes, such as basic biorecognition, enzymatic cleavage, and regulated drug release. In this report, we review natural-based biomaterials that are used in OoCs and their main characteristics. We address the preparation, modification, and characterization methods of natural-based biomaterials and summarize recent reports on their applications in the design and fabrication of micro-tissue models. This article will help bioengineers select the proper biomaterials based on developing new technologies to meet clinical expectations and improve patient outcomes fusing disease modeling.hydrogels, micro-tissue, natural biopolymers, organ-on-a-chip | INTRODUCTIONEngineered micro-tissue models have been used to resemble extracellular matrix (ECM) and natural tissues, with intensive applications ranging from drug injection to sample separation and detection on a single platform. 1 These models can be added to organs-on-chips (OoCs) to precisely monitor cell media across microchannels ranging in size from tens to hundreds of microns. 2 The microchannel has a Berivan Cecen and Ayca Bal-Ozturk contributed equally.

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“…Pharmaceutical applications of polysaccharide NPs involve targeted drug release [143], in vivo drug delivery [144], and stabilizing cosmetic ingredients (e.g., skin and hair care) [145], gene delivery [146], and vaccine delivery [147] as a result of their biodegradability, biocompatibility, muco-adhesive properties, and cellular uptake [148,149]. Cell viability tests have revealed their non-cytotoxicity [150,151], whereas biomedical applications of the polysaccharide NPs involve their use as sensors for the detection of viruses and bacteria [142], tissue engineering [152], wound healing [153], tumor therapy, and delivery of anticancer agents [154].…”

Section: Polysaccharide-and Protein-based Nanoantioxidantsmentioning

confidence: 99%

Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights

Omran

Baek

2021

Molecules

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Free radicals are generated as byproducts of normal metabolic processes as well as due to exposure to several environmental pollutants. They are highly reactive species, causing cellular damage and are associated with a plethora of oxidative stress-related diseases and disorders. Antioxidants can control autoxidation by interfering with free radical propagation or inhibiting free radical formation, reducing oxidative stress, improving immune function, and increasing health longevity. Antioxidant functionalized metal nanoparticles, transition metal oxides, and nanocomposites have been identified as potent nanoantioxidants. They can be formulated in monometallic, bimetallic, and multi-metallic combinations via chemical and green synthesis techniques. The intrinsic antioxidant properties of nanomaterials are dependent on their tunable configuration, physico-chemical properties, crystallinity, surface charge, particle size, surface-to-volume ratio, and surface coating. Nanoantioxidants have several advantages over conventional antioxidants, involving increased bioavailability, controlled release, and targeted delivery to the site of action. This review emphasizes the most pioneering types of nanoantioxidants such as nanoceria, silica nanoparticles, polydopamine nanoparticles, and nanocomposite-, polysaccharide-, and protein-based nanoantioxidants. This review overviews the antioxidant potential of biologically synthesized nanomaterials, which have emerged as significant alternatives due to their biocompatibility and high stability. The promising nanoencapsulation nanosystems such as solid lipid nanoparticles, nanostructured lipid carriers, and liposome nanoparticles are highlighted. The advantages, limitations, and future insights of nanoantioxidant applications are discussed.

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Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Cited by 101 publications

References 346 publications

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

Selection of natural biomaterials for micro‐tissue and organ‐on‐chip models

Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights

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