Abstract:In this paper a number of anticancer agents of natural origin will be presented. Hydroxycamptothecin (HCPT) was found to produce a strong inhibitory action on a variety of animal tumors. It is also effective for treatment of patients with gastric carcinoma, liver carcinoma, tumor of head and neck or leukemia. Pharmacologic studies showed that it could depress S phase of tumor cells significantly and cause formation of cellular chromatid breaks. By means of alkaline elution and nick translation methods it has b… Show more
“…At that time, new biotechnological techniques, including gene transformation and protoplast fusion, were implemented to explore new antibiotics. In the same year, Xu (1991) pointed out that antibiotics like Oxalysine could be e cient treatment methods for cancer and hepatitis. After that, there was a fouryear gap until 1996.…”
Section: Background Of Antibiotics Studies In Chinamentioning
Antibiotics are one of the greatest inventions in human history and are used worldwide on an enormous scale. Besides its extensive usage in medical and veterinary arenas to treat and prevent the infection, its application is very prominent in other elds, including agriculture, aquaculture, and horticulture. In recent decades, the increased consumption of antibiotics in China saw a vast increase in its production and disposal in various environments. However, in this post-antibiotic era, the abuse and misuse of these valuable compounds could lead to the unreversible consequence of drug resistance. In China, antibiotics are given a broad discussion in various elds to reveal their impact on both human/animals health and the environment. To our knowledge, we are the rst paper to look back at the development trend of antibiotic-related studies in China with qualitative and quantitative bibliometric analysis from the past decades. Our study identi ed and analysed 5559 papers from its inception (1991) to December 6, 2021, from the Web of Science Core Collection database. However, with few authors and institutions focusing on long term studies, we found the quality of contributions were uneven. Studies mainly focused on areas such as food science, clinical research, and environmental studies, including Molecular biology, genetics and environmental, ecotoxicology, and nutrition, which indicate possible primary future trends. Our study reports on including potentially new keywords, studies' milestones, and their contribution to antibiotic research. We offer potential topics that may be important in upcoming years that could help guide future research.
“…At that time, new biotechnological techniques, including gene transformation and protoplast fusion, were implemented to explore new antibiotics. In the same year, Xu (1991) pointed out that antibiotics like Oxalysine could be e cient treatment methods for cancer and hepatitis. After that, there was a fouryear gap until 1996.…”
Section: Background Of Antibiotics Studies In Chinamentioning
Antibiotics are one of the greatest inventions in human history and are used worldwide on an enormous scale. Besides its extensive usage in medical and veterinary arenas to treat and prevent the infection, its application is very prominent in other elds, including agriculture, aquaculture, and horticulture. In recent decades, the increased consumption of antibiotics in China saw a vast increase in its production and disposal in various environments. However, in this post-antibiotic era, the abuse and misuse of these valuable compounds could lead to the unreversible consequence of drug resistance. In China, antibiotics are given a broad discussion in various elds to reveal their impact on both human/animals health and the environment. To our knowledge, we are the rst paper to look back at the development trend of antibiotic-related studies in China with qualitative and quantitative bibliometric analysis from the past decades. Our study identi ed and analysed 5559 papers from its inception (1991) to December 6, 2021, from the Web of Science Core Collection database. However, with few authors and institutions focusing on long term studies, we found the quality of contributions were uneven. Studies mainly focused on areas such as food science, clinical research, and environmental studies, including Molecular biology, genetics and environmental, ecotoxicology, and nutrition, which indicate possible primary future trends. Our study reports on including potentially new keywords, studies' milestones, and their contribution to antibiotic research. We offer potential topics that may be important in upcoming years that could help guide future research.
“…irisquinone (Fig. 2) obtained from plant sources like Iridaceaelatea pallasii (Iridaceae) and used in antineoplastic Chinese medicines, has been found to be effective against transplantable rodent tumours [48,49]. It was also isolated from Iris kumaoensis in India [50], and used as a sensitiser for radiation therapy of cancer [51].…”
“…(Iridaceae) has been used in Mongolian traditional medicine for the treatment of diseases such as cancer, inflammation, and bacterial infections. Some benzoquinones isolated from several Iris species have been used as anticancer agents in modern Chinese medicine. − A number of flavones , and isoflavones − have been isolated from other species of this genus. In our continued phytochemical studies on I. bungei , we report here the isolation of four new flavones and an isoflavone.…”
mentioning
confidence: 99%
“…Some benzoquinones isolated from several Iris species have been used as anticancer agents in modern Chinese medicine. [1][2][3][4][5] A number of flavones 6,7 and isoflavones [8][9][10][11] have been isolated from other species of this genus. In our continued phytochemical studies on I. bungei, 12 we report here the isolation of four new flavones and an isoflavone.…”
Four new irisflavones A-D (1-4) and irilin D (5) have been isolated from the underground parts of Iris bungei along with known isoflavones, irilins A-B (6-7) and tlatancuayin (8). The structures of the new compounds were determined using NMR and mass spectroscopic methods and were found to be 2',5,7-trihydroxy-3,6-dimethoxyflavone (1), 2',5-dihydroxy-3,6,7-trimethoxyflavone (2), 2',5,6'-trihydroxy-3,6,7-trimethoxyflavone (3), 3,3',5-trihydroxy-2',7-dimethoxyflavone (4), and 3',4',5,7-tetrahydroxy-6-methoxyisoflavone (5). The structures of irisflavones 1, 3, and 4 were confirmed by single-crystal X-ray diffraction studies.
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