Recent advances in novel drug delivery systems and approaches for management of breast cancer: A comprehensive review

Hani, Umme; Rahamathulla, Mohamed; Osmani, Riyaz Ali M.; Kumar, Honnavalli Yogish; Urolagin, Deeparani; Ansari, Yousuf; Pandey, Kavita; Devi, K. Gayathri; Yasmin, Sabina

doi:10.1016/j.jddst.2020.101505

Cited by 27 publications

(15 citation statements)

References 199 publications

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“…However, precise and relatively novel enzymatic MTGase nano-formulations could lead to a new track for the eradication of BC. 5,77 They may also result in a promising approach for early recognition and its treatment. Targeted enzymatic MTGase therapy is likely to work by attacking specic proteins on cancer cells (or nearby cells) that normally help them grow.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, activation of oncogenes and alteration of tumor suppressor gene pathways lead to the development of cancer. 4,5 The choice of therapy is determined by the size of the primary tumor, the degree of malignancy, and the severity of the disease. 6 During the treatment, it is crucial to inhibit the formation of new blood vessels (angiogenesis), which is responsible for the sustenance of tumor tissues.…”

Section: Introductionmentioning

confidence: 99%

“…6,8,9 Patients with a metastatic stage (invasive BC) are primarily treated with systemic therapies, including chemotherapy, targeted therapy, hormonal therapy, and more recently, immunotherapy. [5][6][7][8] To reduce the growth and division of cancerous cells, different drugs or their combinations are used in combating the disease. 9 However, proven disadvantages such as side effects, inability to adjust the dosage, failure to reach the desired region effectively, and efficiency loss before the targeted area is reached are associated with the conventional chemotherapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Nevertheless, the relapse oen occurs, which is the major drawback in the usual course of action following a diagnosis of BC. 5,11 Besides, they damage healthy cells and tissues, thereby limiting the treatment responses.…”

Section: Introductionmentioning

confidence: 99%

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Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics

et al. 2021

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“…Nanoemulsions Micelles: Micelles are therapeutic agent or a carrier to deliver a poorly water soluble drug having size of around 5-100 nm range. It consists of surfactants having a hydrophilic head and a lipophillic tail [14].…”

Section: Lipid Based Carriersmentioning

confidence: 99%

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

Kola

Nagesh

Roy

et al. 2023

WIREs Nanomed Nanobiotechnol

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The alarming increase in the number of breast cancer patients worldwide and the increasing death rate indicate that the traditional and current medicines are insufficient to fight against it. The onset of chemo-and radioresistances and cancer stem cell-based recurrence make this problem harder, and this hour needs a novel treatment approach. Competent nanoparticle-based accurate drug delivery and cancer nanotheranostics like photothermal therapy, photodynamic therapy, chemodynamic therapy, and sonodynamic therapy can be the key to solving this problem due to their unique characteristics. These innovative formulations can be a better cargo with fewer side effects than the standard chemotherapy and can eliminate the stability problems associated with cancer immunotherapy. The nanotheranostic systems can kill the tumor cells and the resistant breast cancer stem cells by novel mechanisms like local hyperthermia and reactive oxygen species and prevent tumor recurrence. These theranostic systems can also combine with chemotherapy or immunotherapy approaches. These combining approaches can be the future of anticancer therapy, especially to overcome the breast cancer stem cells mediated chemo-and radioresistances. This review paper discusses several novel theranostic systems and smart nanoparticles, their mechanism of action, and their modifications with time. It explains their relevance and market scope in the current era.

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Recent advances in novel drug delivery systems and approaches for management of breast cancer: A comprehensive review

Cited by 27 publications

References 199 publications

Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics

Microbial transglutaminase nanoflowers as an alternative nanomedicine for breast cancer theranostics

Lipid Based Drug Delivery System: A Review

Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

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