Lipid Based Drug Delivery System: A Review

Abstract

Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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“…This technology also aims to solve problems associated with the solubility of poorly water-soluble medicines. In addition, evidence suggests that lipid-based formulations can alter the biodistribution of a drug's toxicity by shifting it away from sensitive organs [ 93 ].…”

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“…Lipid-Based Drug Delivery Systems are an important class of drugs that have attracted the interest of researchers. The flexibility of the lipidic excipients, low-risk profile, amended solubility is some of the advantages favoring a lipid-based drug delivery system as an alternative technique to efficiently deliver poorly soluble drugs 13 . SNEDDS (Self nano emulsifying drug delivery system) is an isotropic, thermodynamically stable mixture of oils, surfactants, and co-surfactants, which, coming in contact with gastrointestinal fluids, leads to the formation of a fine o/w nanoemulsion on gentle agitation.…”