Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

Kola, Prithwish; Nagesh, Prashanth K.B.; Roy, Pritam; Deepak, K; Reis, Rui L.; Kundu, Subhas C.; Mandal, Mahitosh

doi:10.1002/wnan.1876

Cited by 13 publications

(6 citation statements)

References 371 publications

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“…The combined activity of DiD with PDT laser resulted in the efficient production of ROS and further promoted inhibition of tumor growth. An interesting review by Kola et al [ 276 ] presents the combination of chemotherapy with PTT, PDT, and SDT in theranostic nanomedicine applications for effective treatment of breast cancer. This outlines the mechanisms of action and the therapeutic efforts to overcome breast cancer stem cells.…”

Section: Discussionmentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays a crucial role in the clinical therapeutic outcome of conventional treatments and innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering the challenges of the tumor microenvironment (TME), in respect of effective drug accumulation and activity at the tumor site. The main focus is to overcome the obstacles of abnormal vasculature, dense stroma, extracellular matrix, hypoxia, and pH gradient acidosis. In this endeavor, nanomedicines that are targeting distinct features of TME have flourished; these aim to increase site specificity and achieve deep tumor penetration. Recently, research efforts have focused on the immune reprograming of TME in order to promote suppression of cancer stem cells and prevention of metastasis. Thereby, several nanomedicine therapeutics which have shown promise in preclinical studies have entered clinical trials or are already in clinical practice. Various novel strategies were employed in preclinical studies and clinical trials. Among them, nanomedicines based on biomaterials show great promise in improving the therapeutic efficacy, reducing side effects, and promoting synergistic activity for TME responsive targeting. In this review, we focused on the targeting mechanisms of nanomedicines in response to the microenvironment of solid tumors. We describe responsive nanomedicines which take advantage of biomaterials’ properties to exploit the features of TME or overcome the obstacles posed by TME. The development of such systems has significantly advanced the application of biomaterials in combinational therapies and in immunotherapies for improved anticancer effectiveness.

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Section: Discussionmentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

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“…Regarding the fact that therapy resistance and associated subsequent near or distant relapses are common in patients with HNCs [107], the application of smart NPs can especially offer a promising approach to overcome resistance. For breast cancer, several studies have already described novel nanotheranostic systems, which can prevent tumor recurrences [108]. These smart NPs in combination with chemo-and/or immunotherapy have the potential not only to kill tumor cells but can also help to overcome radio-and chemoresistance mediated by cancer stem cells.…”

Section: Applicationsmentioning

confidence: 99%

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

Gül,

Önal Acet,

et al. 2024

IJMS

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Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively overcome biological barriers. Smart designed/tuned nanostructures can be extremely effective for cancer treatment. The selection and design of nanostructures and the adjustment of size and surface properties are extremely important, especially for some precision treatments and drug delivery (DD). By designing specific methods, an important era can be opened in the biomedical field for personalized and precise treatment. Here, we focus on advances in the selection and design of nanostructures, as well as on how the structure and shape, size, charge, and surface properties of nanostructures in biological fluids (BFs) can be affected. We discussed the applications of specialized nanostructures in the therapy of head and neck cancer (HNC), which is a difficult and aggressive type of cancer to treat, to give an impetus for novel treatment approaches in this field. We also comprehensively touched on the shortcomings, current trends, and future perspectives when using nanostructures in the treatment of cancer.

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“…This is particularly relevant for HSCs, which are highly dependent on maintaining genome stability for survival. One recent advancement that may enable tumour selectivity is nanoparticle technology [ 254 ]. These novel platforms involve encapsulating drugs in polymer-lipid hybrid nanoparticles, which recognise antigens associated with CSCs, such as CD44, ALDH1, and CD133, and have been shown to target BCSCs and colorectal CSCs [ 255 , 256 ].…”

Section: Challenges and Opportunities For The Futurementioning

confidence: 99%

DNA Repair and Therapeutic Strategies in Cancer Stem Cells

Gillespie

Ward

Davies

2023

Cancers

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First-line cancer treatments successfully eradicate the differentiated tumour mass but are comparatively ineffective against cancer stem cells (CSCs), a self-renewing subpopulation thought to be responsible for tumour initiation, metastasis, heterogeneity, and recurrence. CSCs are thus presented as the principal target for elimination during cancer treatment. However, CSCs are challenging to drug target because of numerous intrinsic and extrinsic mechanisms of drug resistance. One such mechanism that remains relatively understudied is the DNA damage response (DDR). CSCs are presumed to possess properties that enable enhanced DNA repair efficiency relative to their highly proliferative bulk progeny, facilitating improved repair of double-strand breaks induced by radiotherapy and most chemotherapeutics. This can occur through multiple mechanisms, including increased expression and splicing fidelity of DNA repair genes, robust activation of cell cycle checkpoints, and elevated homologous recombination-mediated DNA repair. Herein, we summarise the current knowledge concerning improved genome integrity in non-transformed stem cells and CSCs, discuss therapeutic opportunities within the DDR for re-sensitising CSCs to genotoxic stressors, and consider the challenges posed regarding unbiased identification of novel DDR-directed strategies in CSCs. A better understanding of the DDR mediating chemo/radioresistance mechanisms in CSCs could lead to novel therapeutic approaches, thereby enhancing treatment efficacy in cancer patients.

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Innovative nanotheranostics: Smart nanoparticles based approach to overcome breast cancer stem cells mediated chemo‐ and radioresistances

Cited by 13 publications

References 371 publications

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

DNA Repair and Therapeutic Strategies in Cancer Stem Cells

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