Recent advances in natural products from plants for treatment of liver diseases

Phytochemical Screening and Hepatoprotective Effect of <i>Alhagi maurorum </i>Boiss (Leguminosae) Against Paracetamol-Induced Hepatotoxicity in Rabbits

“…It has been estimated in recent reports that 10 % of world population is affected with liver diseases including hepatitis, alcoholic steatosis, fibrosis, liver cirrhosis and hepatocellular carcinoma. Morbidity and mortality resulting from liver diseases is a major public health problem worldwide [2]. The management of liver diseases is still a challenge to modern medicine.…”

Crystal structure of (1E,4E)-1,5-bis(4-chlorophenyl)penta-1,4-dien-3-one, C17H12Cl2O

“…Its antioxidant properties and its ability to inhibit the nuclear factor-kappaB (NFkB), which modulates several proinflammatory and profibrotic cytokines provide a rational molecular basis to use it in hepatic disorders [4]. The enone analogues with the 5-carbon spacer (1,1′-distyryl ketones) were found to significantly inhibit the TNFα-induced activation of the transcription factor NFkB more so than curcumin [6].…”

“…Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was first isolated from the plant Curcuma longa two centuries ago and has the potential to treat a wide variety of inflammatory diseases including diabetes, cardiovascular diseases, arthritis and Alzheimer's disease [4,5]. Its antioxidant properties and its ability to inhibit the nuclear factor-kappaB (NFkB), which modulates several proinflammatory and profibrotic cytokines provide a rational molecular basis to use it in hepatic disorders [4].…”

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

“…In addition to our personal experience, we have performed a literature search using mainly Web of Science (WOS), PubMed, and Google search. An extensive number of articles which address many plant constituents with reported experimental (in vitro or in vivo) effects are summarized in various reviews (Alvari et al, 2012;Dhiman et al, 2012;Ding et al, 2012;Girish & Pradhan, 2012;Muriel & Rivera-Espinoza, 2008;Zhang et al, 2013a). In this article, we only consider literature related to the most widely studied active plant constituents of chemically defined molecules with potential hepatoprotective activity and the models most commonly used for their validation.…”