Recent Advances in Multicomponent Reaction Chemistry

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction

“…Isocyanide-based multicomponent reactions [1–3], such as the Ugi reaction, were demonstrated to be very useful in the rapid assembly of complex drug candidates [4], introducing three to four diversity inputs. Furthermore, a nearly limitless variety of heterocycles can be accessed through post-condensation transformations [5–7], adding only one to two steps to the synthetic sequence.…”

Diastereoselective Synthesis of 3,4-Dihydropyran-3-carboxamides with in Vitro Anti-inflammatory Activity

“…By means of multicomponent domino reactions (MCDRs), multiple bonds can be formed consecutively in one pot from several building blocks or from an in situ-formed intermediate with a strategically positioned reactive site. − It is well-known that functionalized 1,4-dihydropyridines can readily be prepared in one pot via a four-component reaction of Hantzsch reagents (aldehydes, amines, and two 1,3-dicarbonyl molecules). − Technically, however, treatment of Hantzsch reagents could also result in another structure, 2-amino-3,4-dihydropyran, via nucleophilic attack of enolate to the electron-deficient imine in the final step of cyclization. Considering the above points and our continued interest in the one-pot synthesis of heterocyclic compounds − wherein iodine is used as a Lewis acid catalyst, we designed a five-component Hantzsch-type reaction (Figure ) to construct a novel molecule bearing a 2-amino-3,4-dihydropyran-3-carboxamide core.…”

Sodium Saccharin as an Effective Catalyst for Rapid One-pot Pseudo-five Component Synthesis of Dihydropyrano[ 2,3-g]chromenes under Microwave Irradiation

“…Consequently, this field has attracted great attention in recent years. [3][4][5] During MCRs, target compounds are produced with greater efficiency by generating structural complexity in a single step from three or more reactants. 6,7 Chromenes and their derivatives have a wide range of applications in various fields of chemistry, biology and pharmacology.…”