Sodium Saccharin as an Effective Catalyst for Rapid One-pot Pseudo-five Component Synthesis of Dihydropyrano[ 2,3-g]chromenes under Microwave Irradiation

Abstract

One-pot microwave-assisted synthesis of dihydropyrano[2,3-g]chromenes catalyzed by sodium saccharin as an efficient, mild and green catalyst was studied. The method presented is a safe and eco-friendly approach for the multicomponent synthesis of dihydropyrano[2,3-g]chromene derivatives with many merits including short reaction times (in comparison with other reported results), high yields and easy work up.

Synthesis and In Vitro Cytotoxicity of Novel Halogenated Dihydropyrano[3,2-b]Chromene Derivatives

“…The structures of compounds (6a-j) were determined on the basis of their elemental analyses, 1 H and 13 C NMR and IR spectroscopic data. In similar studies heteroannelation of cyclic ketones were conducted by use of catalysts like sodium carbonate, sodium saccharine and poly(4-vinylpyridine); [20][21][22]…”

Artificial sugar saccharin and its derivatives: role as a catalyst

“…Mechanism for the formation of desired product is shown in Scheme 63. 76 The reaction procedure carried out in microwave irradiation, easy workup and short reaction condition with high yields of products. 9.…”

Synthesis of benzo[b]xanthene‐triones and tetrahydrochromeno[2,3‐b]xanthene tetraones via three‐ or pseudo–five‐component reactions using Fe3O4@SiO2/PEtOx as a novel, magnetically recyclable, and eco‐friendly nanocatalyst

“…They have been employed as cognitive enhancers, for the treatment of neurodegenerative diseases, including Alzheimer disease, amyotrophic lateral sclerosis, Parkinson disease, and Huntington disease. [27,28] Many methods have been reported for the synthesis of chromene and benzo[b]xanthene derivatives by reaction of aldehydes, malononitrile, cyclic-1,3-dicarbonyl and α,β-unsaturated carbonyl compounds in the presence of Fe(DS) 3 , [29] Me/TaMCF, [30] sodium phthalimide/ [BMIM]BF 4 , [31] CNT@meglumune, [32] Fe 3 O 4 @SiO 2 -BenzIm-Fc[Cl]/BiOCl nanocomposite, [33] TEAA, [34] DABCO, [35] PTSA, [36] [bmim][Br], [37] PS/GaCl 3 , [38] and Fe 3 O 4 /PEG/succinic anhydride. [39] Notwithstanding all advantages of these catalysts, they mostly suffer from long reaction times, multiple reaction steps, hard workup procedures, moderate yields, and nonrecyclable ability.…”