Artificial sugar saccharin and its derivatives: role as a catalyst

Abstract

The primary objective of this review was to demonstrate the significance of artificial sugar saccharin and its derivatives as catalysts for a wide variety of organic transformation.

Versatile Quinazolinone Synthesis: N‐Bromosaccharin‐Catalyzed Divergence in 2,3‐Dihydroquinazolin‐4(1H)‐one and Quinazolin‐4(3H)‐one Formation

“…Having established efficient protocols for the preparation of 2,3-diphenyl-2,3-dihydroquinazolin-4(1H)-one through the condensation reaction of isatoic anhydride with aldehydes and ammonium salts (or amines), it is observed that an unexpected product were isolated, after characterisation it was revealed that the catalyst exhibited a catalyzed cyclization and a subsequent oxidation of 2,3-dihydroquinazolin-4(1H)-ones. N-Bromosaccharin was identified as a chemoselective nitrogen radical precursor that undergoes controllable homolytic cleavage under ambient light irradiation [32] and also taking the oxidizing property of N-Bromosaccharin [25][26][27][28][29] into account, we have tried to optimize the reaction conditions for the oxidation of 2,3-dihydroquinazolin-4(1H)-ones to 2-quinazolin-4(3H)-ones (Table 2) in presence of visible light. For this, 2,3-dihydroquinazolin-4(1H)-one (4 a) was taken as model reactant.…”

“…[24] N-Bromosaccharin (NBSac) is an excellent reagent due to its characteristics such as easy preparation, low cost and non-metallic nature but it is rarely used in organic synthesis. [25] It act as a brominating agent. [26] It is also used as a catalyst for oxidative cleavage of oximes to the corresponding aldehydes and ketones, [27] chemoselective oxidation of thiols to their corresponding disulfides, [28] and synthesis of oxathiolane from aldehydes and ketones with 2-mercaptoethanol.…”

The Ritter reaction of N‐(hydroxymethyl)saccharin with nitriles

“…Therefore, intensive efforts have been made toward the synthesis of new saccharine derivatives as potential bioactive compounds [17]. In addition, the application of these derivatives in catalysis [18], polymers [19] and coordination chemistry [20] has significantly increased.…”

HPTLC screening of saccharin in beverages by densitometry quantification and SERS confirmation

“…As an important additive in the food industry, the safety issue of saccharin, however, became disputable since the 1970s, concerning its potential adverse health effects. 1,2 Moreover, exposure to saccharin may disrupt intestinal epithelial cell barrier function in vitro, as evidenced by Santos. 3 As such, the Food and Drug Administration of the United States officially prohibited the addition of saccharin into food once in 1977, which was repealed later.…”