Recent advances in MoS₂-based photothermal therapy for cancer and infectious disease treatment

Abstract

MoS2-based PTT with high therapeutic efficacy and minimal side-effects could show potential for improving cancer and infectious disease treatments.

MoS2-based nanocomposites for cancer diagnosis and therapy

“…Two-dimensional nanomaterials (MoS 2 , MoSe 2 , WS 2 , WSe 2 , and etc.) have attracted great interest in the biomedical field [ 8 , 18 , [386] , [387] , [388] , [389] , [390] , [391] , [392] , [393] , [394] , [395] , [396] , [397] ], especially MoS 2 -based nanocomposites due to their outstanding physi-chemical properties and good biocompatibility. MoS 2 with a large specific surface area can load various biomolecules, drugs, fluorescent molecules, and other nanomaterials to improve its colloidal stability and tumor targeting, increase its sensitivity and accuracy in detecting specific biomarkers, and enhance its specific response to the stimulation of tumor microenvironment, which reduces side effects during treatment.…”

Recent Progress on NIR-II Photothermal Therapy

“…The key to the applications of the NIR-II absorption materials in PTT is that the materials should have good photothermal conversion efficiency, low biological toxicity and easy functionalization. Studies show that Au nanomaterials ( Deng et al, 2019 ; Song et al, 2019 ; Wang et al, 2020c ; Jia et al, 2020 ), metal sulfur oxides ( Lin et al, 2020a ; Sun et al, 2021 ) such as Ag 2 S ( Yang et al, 2017b ) and MoO 2 ( Guo et al, 2020 ), two-dimensional nanomaterials such as MoS 2 ( Shi et al, 2020 ), niobium carbide (MXene) ( Lin et al, 2017b ) and SnTe ( Zhang et al, 2019a ), and polymers ( Sun et al, 2019a ) such as semiconductor polymer nanoparticles SPN 1 ( Jiang et al, 2018b ), SPN 2 ( Yin et al, 2020 ), SPN 3 ( Cao et al, 2018b ) can be applied for NIR-II PTT. By modifying the photothermal materials, researchers can improve their photostability, chemical stability, biocompatibility, and endow them with some new functions, such as targeting and drug delivery.…”

Synthesis of photothermal antimicrobial cotton gauze using AuNPs as photothermal transduction agents

“…Photothermal therapy (PTT) is based on the photothermal effect of photothermal transduction agents (PTAs), 17,18 which could transform light energy into heat, causing cell membrane rupture of microbial cells. 19 Compared with traditional antimicrobial therapy methods, PTT exhibits many advantages such as short treatment time, broad spectrum antibacterial ability and negligible resistance effect.…”