Recent Advances in Metal-Organic Framework-Based Electrochemical Biosensing Applications

Abstract

In the face of complex environments, considerable effort has been made to accomplish sensitive, accurate and highly-effective detection of target analytes. Given the versatility of metal clusters and ligands, high porosity and large specific surface area, metal–organic framework (MOF) provides researchers with prospective solutions for the construction of biosensing platforms. Combined with the benefits of electrochemistry method such as fast response, low cost and simple operation, the untapped applications of MOF for biosensors are worthy to be exploited. Therefore, this review briefly summarizes the preparation methods of electroactive MOF, including synthesize with electroactive ligands/metal ions, functionalization of MOF with biomolecules and modification for MOF composites. Moreover, recent biosensing applications are highlighted in terms of small biomolecules, biomacromolecules, and pathogenic cells. We conclude with a discussion of future challenges and prospects in the field. It aims to offer researchers inspiration to address the issues appropriately in further investigations.

Systematic Investigation on the Electrochemical Performance of Pristine Silver Metal–Organic Framework as the Efficient Electrode Material for Supercapacitor Application

“…The combination of the pristine MOFs with other electrode materials may display an optimistic synergistic effect which helps greatly to improve the electrochemical performance of the fabricated device and improve material stability. − …”

Nanomaterial interfaces designed with different biorecognition elements for biosensing of key foodborne pathogens

“…MOFs are advanced nanomaterials, and they are constructed as a result of the self‐assembly of organic ligands and inorganic metal‐containing nodes (Annamalai et al., 2022). High specific surface areas, the exceedingly ordered pores, tunable pore sizes, and simple synthesis make them promising candidates in sensing applications (; Li, Zhang, et al., 2021). However, poor chemical stability is their disadvantage.…”

Photoactive MOF-Derived Bimetallic Silver and Cobalt Nanocomposite with Enhanced Antibacterial Activity

“…16−18 In addition, phage therapy is bacterial-selective, making its use controversial because of the existence of phages that are less desirable for therapeutic use owing to their narrow target range and poor pharmacokinetics. 19,20 Recently, metal−organic frameworks (MOFs) have emerged as promising materials with broad and versatile applicability in catalysts, 21,22 sensors, 23,24 energy storage fields, 25,26 and biomedical fields, including antibacterial treatment. 27,28 MOFs are composed of a node metal or metal oxide and an organic linker ligand and exhibit stable chemical structures with high specific surface areas and porosities.…”

“…Recently, metal–organic frameworks (MOFs) have emerged as promising materials with broad and versatile applicability in catalysts, , sensors, , energy storage fields, , and biomedical fields, including antibacterial treatment. , MOFs are composed of a node metal or metal oxide and an organic linker ligand and exhibit stable chemical structures with high specific surface areas and porosities. Thus, MOFs can be used as reservoirs for antibacterial metal ions such as Cu 2+ , Zn 2+ , Co 3+ , and Ag + , and the decomposition of their frameworks under triggered environments such as living organisms or external stimuli conditions can cause the continuous and sustained release of metal ions, resulting in a prolonged antibacterial effect. , …”