Recent advances in industrial fermentation in Japan

Large Scale Industrial Enzyme Production

“…Blockage of membrane due to suspended solids or gel layer build-up, hence reduction in flow rates pH, ionic strength, pigments can all adversely affect the membrane Downloaded by [Deakin University Library] at 00: 19 12 August 2015 T o date its major use has been in the concentration of various proteins from whey''' and bloodio8 and for vaccine and virus c o n~e n t r a t i o n~~' where the hollow fiber-type system produced by Amicon, namely, the DC30 is used to concentrate volumes up to400 II at rates of 50 Q/ hr.…”

“…Thus trypsin bound to the water-soluble form can be made insoluble by changes in pH, removed from the extract by solid-liquid separation techniques, and then recovered from the complex. The use of methods such as this in Downloaded by [Deakin University Library] at 00:19 12 August 2015 …”

“…More specifically DeLaneyE4 has reviewed industrial gel filtration of proteins and Graves and Wu*' affinity chromatography. Downloaded by [Deakin University Library] at 00:19 12 August 2015 …”

L-Phenylalanine Production in Continuous Culture Using a Hyperproducing Mutant of Escherichia Coli K-12

“…Most of the past research has involved the selection and improvement of strains of Corynebacterium glutamicum (Tokoro et al, 1970;Hagino and Nakayama, 1973;Nakayama et al, 1973;Yamada, 1977;Hirose and Shibai, 1980) or Brevibacterium spp. (Nakayama et al, 1973;Tsuchida et al, 1975;Akashi et al, 1979;Hirose and Shibai, 1980) for maximum volumetric productivity.…”

Lactobacillus brevis Strains from Fermented Aloe vera Survive Gastroduodenal Environment and Suppress Common Food Borne Enteropathogens

“…Plant-derived LABs were first investigated in Japan [40]. These studies focused on the isolation of acid and bile tolerant LAB because plant-derived LAB are much more resistant to artificial gastric juices and bile than animal-derived LAB [7], [36].…”