Recent Advances in Dendrimer Research for Cardiovascular Diseases

Yu, Maomao; Xu, Jie; Xu, Lu; Chen, Cong; Shen, Wanli; Cao, Yini; Lian, Guan; Qi, Rong

doi:10.1021/acs.biomac.5b00979

Cited by 48 publications

(26 citation statements)

References 103 publications

(164 reference statements)

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“…Biocompatible nanosized PAMAM dendrimers have been used extensively in several fields such as biomedical, sensor and catalysis applications and information storage [13][14][15][16] . This is mainly due to its spherical shape (3D structure), high density of surface active groups, good structural homogeneity, good biocompatibility and so on 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical amination of graphene using nanosized PAMAM dendrimers for sensing applications

et al. 2016

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In this work, a graphene film was electrochemically functionalized by anodic oxidation of amine terminated PAMAM (4th generation PAMAM-(NH2)64) dendrimer molecules via covalent linkage (C-N) between graphene and PAMAM. In this, the simple functionalization provides ≈37.51×10 15 PAMAM molecules cm -2 on the versatile graphene, which is ten times higher than the PAMAM molecules attached on GCE (3.33×10 15 molecules cm -2 ). Thus, the facile electrochemical functionalization route on graphene yields a high density of amine functional groups on graphene which offers an opportunity to load more number of enzymes, proteins, DNA, antibodies, antigens, etc. to develop highly sensitive graphene based bio and chemical sensors. To demonstrate this with a model, horseradish peroxidase (HRP) enzyme was chosen and immobilized onto the functionalized graphene film to detect H2O2. The so constructed platform shows enhanced electrocatalytic activity, high storage stability up to one month, lower applied potential and exhibits a high sensitivity of 29.86 µA mM -1 cm 2 which was 5 times greater than the functionalized GCE for the detection of H2O2. The sensor was also used to detect H2O2 in human serum to testify the feasibility of the sensor in practical application. These results demonstrate that the electrografting of PAMAM on graphene is a promising approach for the fabrication of the sensors which exhibit enhanced electrocatalytic activity, sensitivity and stability.

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Section: Introductionmentioning

confidence: 99%

Electrochemical amination of graphene using nanosized PAMAM dendrimers for sensing applications

et al. 2016

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“…39 The fields of vascular and cardiac surgery will see the influence of targeted therapies to treat atherosclerotic lesions as well as prevent re-stenosis after interventions. 48, 53, 57, 63 Finally, the field of trauma surgery and military medicine will benefit from therapeutics being developed to stop hemorrhage. 49, 64 In summary, we have described how targeted therapeutics are designed in regards to the delivery vehicle platform, targeting moiety, and method of delivering a therapeutic agent, and discussed the many applications of this emerging field to the treatment of surgical diseases.…”

Section: Resultsmentioning

confidence: 99%

Targeted Nanotherapies for the Treatment of Surgical Diseases

Morgan¹,

Wasserman²,

Kibbe³

2016

Annals of Surgery

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Objective To describe the components of targeted nanotherapeutics and to review their applications in the treatment of surgical diseases. Background Targeted nanotherapeutics is a novel strategy for treating a variety of diseases and is an emerging technology that offers advantages over current treatment strategies. The nanoscale size, combined with the ability to surface functionalize the delivery vehicle to enable targeting and incorporate a therapeutic payload, provide a new and innovative therapeutic platform to treat surgical diseases that has yet to be fully realized in the surgical arena. Methods A comprehensive literature review of nanotherapeutics, targeting strategies, and their utility in treating surgical diseases is performed. Results Targeted nanotherapeutics have demonstrated safety and biocompatibility in treating surgical diseases. The ability to surface functionalize the nanoparticles affords a unique tailorability that enables targeting specificity and therapeutic payload delivery to treat a variety of surgical diseases. Moreover, the small size and targeting capabilities allow access to biological compartments, such as the blood-brain-barrier, that have previously been difficult to treat. Conclusions Targeted nanotherapeutics represents a novel therapeutic platform and has great potential to impact the treatment of surgical diseases.

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“…The exclusivity of these properties to dendritic molecules gives rise to the possibility for their use as drug delivery systems. The improved efficacy and lower leakage percentages in dendrimers make them more suitable in various formulations, including oral, ocular, and transdermal, since the pharmacokinetic parameters for dendrimers are also promising (Yu et al 2015).…”

Section: Dendrimersmentioning

confidence: 99%

The use of nanotechnology in cardiovascular disease

2018

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Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the incidence of cardiovascular disease is increasing. These contributing factors, coupled with more advanced methods of diagnosis, have delivered statistics that clearly show that there is a rising trend in the prevalence of cardiovascular disease. Treatment for cardiovascular diseases is limited currently to oral medicines or invasive surgery. There is a huge gap in this area of medicine for novel therapeutics for improved patient outcomes. Nanotechnology may provide a solution to more effective treatment of disease, with better prognoses and a reduced side effect profile. This review will explore for potential solutions to the limited pharmacological therapies currently on the market and the future that lies ahead for the place of nanotechnology within cardiovascular medicine.

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Recent Advances in Dendrimer Research for Cardiovascular Diseases

Cited by 48 publications

References 103 publications

Electrochemical amination of graphene using nanosized PAMAM dendrimers for sensing applications

Electrochemical amination of graphene using nanosized PAMAM dendrimers for sensing applications

Targeted Nanotherapies for the Treatment of Surgical Diseases

The use of nanotechnology in cardiovascular disease

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