Targeted Nanotherapies for the Treatment of Surgical Diseases

Abstract

Objective To describe the components of targeted nanotherapeutics and to review their applications in the treatment of surgical diseases. Background Targeted nanotherapeutics is a novel strategy for treating a variety of diseases and is an emerging technology that offers advantages over current treatment strategies. The nanoscale size, combined with the ability to surface functionalize the delivery vehicle to enable targeting and incorporate a therapeutic payload, provide a new and innovative therapeutic platform to treat surgical diseases that has yet to be fully realized in the surgical arena. Methods A comprehensive literature review of nanotherapeutics, targeting strategies, and their utility in treating surgical diseases is performed. Results Targeted nanotherapeutics have demonstrated safety and biocompatibility in treating surgical diseases. The ability to surface functionalize the nanoparticles affords a unique tailorability that enables targeting specificity and therapeutic payload delivery to treat a variety of surgical diseases. Moreover, the small size and targeting capabilities allow access to biological compartments, such as the blood-brain-barrier, that have previously been difficult to treat. Conclusions Targeted nanotherapeutics represents a novel therapeutic platform and has great potential to impact the treatment of surgical diseases.

Systemically administered collagen-targeted gold nanoparticles bind to arterial injury following vascular interventions

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“…Nanotechnology is an emerging platform for the targeted delivery of therapeutics and imaging modalities (Agyare and Kandimalla ; Morgan et al. ; Rink et al. ; Thaxton et al.…”

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