Recent advances in colon drug delivery systems

Shape memory materials and 4D printing in pharmaceutics

“…for the treatment of local pathologies, such as gastric ulcers or inflammatory bowel disease that affects the colonic region [151][152][153][154][155][156][157][158][159]. However, the possibility of increasing the DDS residence time and prolonging the release of the loaded drug in the upper gastrointestinal tract, even in the esophagus, would also be beneficial.…”

Screening of main factors in microencapsulation of two Bifidobacterium strains by spray drying

“…Colon target delivery systems of bioactive compounds present advantages because the colon has prolonged transit time, decreased digestive enzyme activities, and a near neutral pH and has been proven to show good bioavailability for peptides and other bioactive compounds. Colon target delivery systems also provide treatment for different local pathologies (Arévalo-Pérez et al, 2020). However, colon-targeted delivery systems are still in an early stage in the field of food science (Feng et al, 2020).…”

“…Recently, the use of not so common biopolymers such as nopal mucilage with alginate has been explored (Velázquez-Gutiérrez et al, 2020). However, Feng et al (2020) and Arévalo-Pérez et al (2020) carried out thorough reviews of the polymers studied for the delivery of different bioactive compounds, and the performance of pectin, carboxymethylcellulose, polyethylene oxide, hydroxypropyl methylcellulose PLGA, polymethacrylates and alginate stands out.…”

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

“…Amongst, "smart" chemotherapy using stimuli-responsive hydrogels based on natural polymers have received more interest owing to intrinsic physicochemical and biological properties of these drug delivery systems (DDSs). [5][6][7][8][9] Amongst the variety of natural polymers, gelatin (Gel) as a thermo-sensitive natural polypeptide is widely used for the fabrication of de novo DDSs. It isolated from animal collagen through partial acidic (type A), alkaline (type B), or enzymatic hydrolysis that can be utilize in pharmaceutical technology as hard or soft capsules.…”

“…Despite the specific advantages of above‐mentioned approaches, off‐targeting of their have been challenged in most cases. Amongst, “smart” chemotherapy using stimuli‐responsive hydrogels based on natural polymers have received more interest owing to intrinsic physicochemical and biological properties of these drug delivery systems (DDSs) 5–9 …”