Recent advances in biosensor development for the detection of cancer biomarkers

Jayanthi, V.S.P.K. Sankara Aditya; Das, Asim Bikas; Saxena, Urmila

doi:10.1016/j.bios.2016.12.014

Cited by 403 publications

(185 citation statements)

References 122 publications

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“…To the contrary, there was no statistically significant association of total cholesterol with DR. These results are consistent with several other studies, Ahmed et al (2016) and Jayanthi et al (2017). The Singapore Malay Eye study reported that higher cholesterol levels could have a good role in retinopathy, Wong et al (2008), while CrosbyNwaobi and co-authors Crosby-Nwaobi et al (2015) reported no lipid profile association with progression of DR.…”

Section: Discussionsupporting

confidence: 89%

Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

et al. 2020

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Background: Diabetic retinopathy is one of the common microvascular complications of diabetes. The formation of advanced glycation end products (AGE) exerts deleterious effects by acting directly to induce cross-linking of proteins promoting vascular damage. Hyperglycemia causes disturbance in glycogenesis pathway resulting in reduction of glucose to sorbitol which is converted to fructose by sorbitol dehydrogenase. Methods: The levels of advanced glycation end products (AGE), lipid profile, and glycosylated Hb were estimated in 266 type I diabetic patients without retinopathy, patients with nonproliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy patients (PDR).The association between genotypes of two polymorphisms of sorbitol dehydrogenase gene (SDH) was estimated in the promoter region: a C/G transversion located at _1214 position and a G/C transversion at _888 position. This study showed allele-specific PCR for C-1214G polymorphism and restriction fragment length polymorphism (RFLP) technique for a G/C transversion at _ 888 position. Results: Significant increase was detected in glycosylated Hb levels in diabetic group, both with retinopathy and without retinopathy. Also, a significant increase in Hb1c in PDR group compared to NPDR. Significant increase in total cholesterol, HDL, TG, and AGE in PDR group compared to the group without retinopathy. No significant change was observed in the same parameter between PDR and NPDR group. Significant increase in AGE in both PDR and NPDR group compared to the group without retinopathy. No significant change in PDR group compared to NPDR. The results of this study showed no significant difference in genotype distribution (C/C, C/G, G/G) of the C˗1214G polymorphism between the two groups of patients with and without DR A2-. There was no statistically significant difference between the three genotypes (CC, CG, and GG) of the C˗1214G polymorphism in relation to DR severity in male genders. However, there was a statistically significant difference in female gender with increased frequency of CC genotype (2.7%, 21.9%, and 23.7%). There was no significant difference in genotype distribution (C/C, G/C, and G/G) of the G˗888C polymorphism between the two groups of patients with DR and without DR. However, the CC genotype occurred more frequently in patients with DR than patients without DR (6.7% vs. 3.9%), and G/G genotype occurred more frequently in

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Section: Discussionsupporting

confidence: 89%

Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

et al. 2020

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“…Advantages and limitations of these methods have been compared for the prostate specific antigen (PSA) biomarker detection [159]. Different cancer biosensors and their characteristics were recently reported [160]. Aptamers are a class of bio-recognition element which can be used as molecular tools for clinical diagnosis [161,162].…”

Section: Applications Of Aptamers In Oncologymentioning

confidence: 99%

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

Mercier

Dontenwill

Choulier

2017

Cancers

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Aptamers are nucleic acids referred to as chemical antibodies as they bind to their specific targets with high affinity and selectivity. They are selected via an iterative process known as ‘selective evolution of ligands by exponential enrichment’ (SELEX). Aptamers have been developed against numerous cancer targets and among them, many tumor cell-membrane protein biomarkers. The identification of aptamers targeting cell-surface proteins has mainly been performed by two different strategies: protein- and cell-based SELEX, when the targets used for selection were proteins and cells, respectively. This review aims to update the literature on aptamers targeting tumor cell surface protein biomarkers, highlighting potentials, pitfalls of protein- and cell-based selection processes and applications of such selected molecules. Aptamers as promising agents for diagnosis and therapeutic approaches in oncology are documented, as well as aptamers in clinical development.

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“…4,5 The methods currently used to detect cancer biomarkers mainly include chemiluminescent immunoassay, enzyme-linked immunosorbent assay (ELISA), immuno-blotting, electrochemical immunoassay, and time-resolved uorescence immunoassay. [6][7][8][9][10] Although these methods are well elaborated and widely used in clinical laboratories, they still exhibit shortcomings, such as tedious operation process, long testing time, and the use of expensive equipment or unstable reagents, in real-time detection of biomarkers. These drawbacks have hindered their wide pointof-care testing (POCT) applications, particularly in lowresource settings, such as clinics, inrmaries, and homes.…”

Section: Introductionmentioning

confidence: 99%

Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods

Liu

et al. 2020

RSC Adv.

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Recent advances in biosensor development for the detection of cancer biomarkers

Cited by 403 publications

References 122 publications

Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

Role of advanced glycation end products and sorbitol dehydrogenase in the pathogenesis of diabetic retinopathy

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers

Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods

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