Recent Advances in Antiviral Nucleosides

Gumina, Giuseppe; Choi, Yongseok; Chu, Chung K.

doi:10.1016/b978-044451319-9/50001-4

Cited by 7 publications

(4 citation statements)

References 329 publications

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“…NMR spectroscopy confirmed the formation of E isomers which is a most favored confirmation and reported in similar type of reactions (Gumina and Chu, 2003; Tenchiu et al, 2009). An excellent example of the reactivity of N - N binucleophiles is attributed in the reaction of 1 and 2 with 3-methyl-1 H -pyrazole-5-amine yielding 7 and 14 respectively.…”

Section: Introductionsupporting

confidence: 78%

Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides

et al. 2018

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Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utilizing same strategy, we propose the synthesis of diversified C-nucleosides (3-14) by reaction with N,N dinucleophiles. These nucleoside analogs were than tested against viral, bacterial and fungal strains.

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Section: Introductionsupporting

confidence: 78%

Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides

et al. 2018

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“…The conditions were improved by using our previous studies (Kovalovs et al, 2013;Novosjolova et al, 2013). For the biological activity of purine nucleosides, their anticancer and antiviral activity and use as agonists and antagonists of adenosine receptors, see: Lech-Maranda et al (2006); Robak et al (2009); Gumina et al (2003); Fredholm et al (2011); Elzein & Zablocki (2008). For the structure of another 2,6-dichloropurine ribonucleoside, 9-(2 0 -deoxy-3 0 ,5 0 -di-O-4-methoxybenzoyl--d-ribofuranosyl)-2,6-dichloro-9H-purine, see: Yang et al (2012).…”

Section: Related Literaturementioning

confidence: 99%

“…well known of their biological activity: anticancer and antiviral activities, and as agonists and antagonists of adenosine receptors(Lech-Maranda et al (2006),Robak et al (2009),Gumina et al (2003),Fredholm et al (2011),Elzein & Zablocki (2008).…”

mentioning

confidence: 99%

2,6-Dichloro-9-(2′,3′,5′-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

et al. 2014

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The title synthetic analog of purine nucleosides, C16H16Cl2N4O7, has its acetylated β-furanose ring in a 3′β-envelope conformation, with the corresponding C atom deviating by 0.602 (5) Å from the rest of the ring. The planar part of the furanose ring forms a dihedral angle of 65.0 (1)° with the mean plane of the purine bicycle. In the crystal, molecules form a three-dimensional network through multiple C—H⋯O and C—H⋯N hydrogen bonds and C—H⋯π interactions.

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“…1,2 It is most prevalent in Asia, Africa, Southern Europe and Latin America, where the prevalence of hepatitis B surface antigen (HBsAg) carriers in the general population ranges from 2% to 20%. 3 Interferon has been shown to be effective against HBV, but it requires inconvenient injection therapy.…”

Section: Introductionmentioning

confidence: 99%