Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides

Bari, Ahmed; Ali, Syed Sohail; Alanazi, Amer M.; Mashwani, Muhammad A.; Al‐Obaid, Abdulrahman M.

doi:10.3389/fchem.2018.00294

Cited by 3 publications

(2 citation statements)

References 17 publications

(17 reference statements)

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“…Compounds 36 and 37 (Figure 3) persuaded cellular toxicity for the viral strains, but they were deficient compared to the two controls used. Moreover, the lower cytotoxicity of acyclic nucleosides was because of the benzyl-protecting groups, which resulted in low solubility and, hence, low availability of the virus [79].…”

Section: Pyrazole Derivativesmentioning

confidence: 99%

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

Ahmad,

Sohail,

Bilal

et al. 2024

Molecules

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Viruses are a real threat to every organism at any stage of life leading to extensive infections and casualties. N-heterocycles can affect the viral life cycle at many points, including viral entrance into host cells, viral genome replication, and the production of novel viral species. Certain N-heterocycles can also stimulate the host’s immune system, producing antiviral cytokines and chemokines that can stop the reproduction of viruses. This review focused on recent five- or six-membered synthetic N-heterocyclic molecules showing antiviral activity through SAR analyses. The review will assist in identifying robust scaffolds that might be utilized to create effective antiviral drugs with either no or few side effects.

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Section: Pyrazole Derivativesmentioning

confidence: 99%

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

Ahmad,

Sohail,

Bilal

et al. 2024

Molecules

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“…Because formyl sugars have both electron-donating as well as electron-withdrawing properties, the molecule is more vulnerable to attack by a nucleophile. Bari and co-workers 67 synthesized a variety of C -nucleosides 64 – 69 by reactions with N , N -dinucleophiles using a similar strategy (Scheme 15 ). A novel methodology was utilized for the synthesis of pyrazole-acyclo- C -nucleoside 64 by reacting formyl-bearing sugar 6a with cyanoethylhydrazine in refluxing ethanol.…”

Section: Applications Of C -2-formyl Glycalsmentioning

confidence: 99%

Recent Advances in the Synthesis and Application of C-2-Formyl Glycals

et al. 2023

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Since last couple of decades, C-2-formyl glycals have sustained interest in carbohydrate chemistry as they afford valuable chiral building blocks for many biological / pharmaceutical / industrial based important molecules. Basically, C-2-formyl glycals are a class of carbohydrates incorporating an α,β-unsaturated aldehyde. Therefore in many organic reactions, the C-2-formyl-glycals molecule could therefore serve as an α,β-unsaturated aldehyde core. In this review, we have compiled a literature survey on the synthesis of C-2-formyl-glycals and further their importance for the synthesis of many medicinal, supramolecular, biological, organic as well as material chemistry-based molecules.

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