2,6-Dichloro-9-(2′,3′,5′-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Abstract

The title synthetic analog of purine nucleosides, C16H16Cl2N4O7, has its acetyl­ated β-furan­ose ring in a 3′β-envelope conformation, with the corresponding C atom deviating by 0.602 (5) Å from the rest of the ring. The planar part of the furan­ose ring forms a dihedral angle of 65.0 (1)° with the mean plane of the purine bicycle. In the crystal, mol­ecules form a three-dimensional network through multiple C—H⋯O and C—H⋯N hydrogen bonds and C—H⋯π interactions.

Sulfonyl Group Dance: A Tool for the Synthesis of 6-Azido-2-sulfonylpurine Derivatives

“…Compounds 1, 6, 8, and 10 were prepared according to existing literature procedures. 25,27,60 Sodium Sulfinates. Commercially unavailable sulfinates, sodium octane sulfinate, sodium 2-phenylethane sulfinate, and sodium 2propane sulfinate, were prepared according to existing literature, 41 and sodium 1-dodecane sulfinate was prepared according to literature.…”