Recent advancement in biomedical applications on the surface of two-dimensional materials: from biosensing to tissue engineering

Nguyen, Emily P.; Silva, Cecilia de Carvalho Castro; Merkoçi, Arben

doi:10.1039/d0nr05287f

Cited by 54 publications

(26 citation statements)

References 222 publications

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“… 44 , 45 Two-dimensional (2D) nanomaterials such as graphene permit the fabrication of ultrasensitive semiconductors functionalized with bioreceptors for the specific detection of small molecules, proteins, and DNA. 45 − 48 …”

Section: The Nanodiagnostic Devices Scenariomentioning

confidence: 99%

Nanodiagnostics to Face SARS-CoV-2 and Future Pandemics: From an Idea to the Market and Beyond

et al. 2021

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The COVID-19 pandemic made clear how our society requires quickly available tools to address emerging healthcare issues. Diagnostic assays and devices are used every day to screen for COVID-19 positive patients, with the aim to decide the appropriate treatment and containment measures. In this context, we would have expected to see the use of the most recent diagnostic technologies worldwide, including the advanced ones such as nano-biosensors capable to provide faster, more sensitive, cheaper, and high-throughput results than the standard polymerase chain reaction and lateral flow assays. Here we discuss why that has not been the case and why all the exciting diagnostic strategies published on a daily basis in peer-reviewed journals are not yet successful in reaching the market and being implemented in the clinical practice.

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Section: The Nanodiagnostic Devices Scenariomentioning

confidence: 99%

Nanodiagnostics to Face SARS-CoV-2 and Future Pandemics: From an Idea to the Market and Beyond

et al. 2021

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“…Two-dimensional (2D) nanomaterials have come into the limelight starting with the discovery of graphene in 2004 [34]. Besides atomic layer thickness, tunable electronic properties, good mechanical strength and chemical activity, they feature a high surface-to-volume ratio making them good candidates for electrochemical biosensing, gas sensing, energy conversion, storage devices and many other biomedical applications [35][36][37][38]. Besides graphene and its derivatives, research has focused on the development of other emerging 2D nanomaterials including boron nitride, graphite carbon nitride, transition metal dichalcogenides, MXenes, black phosphorous, transition metal oxides and also, more recently, heterostructures incorporating at least one 2D nanomaterial [39][40][41].…”

Section: Nanomaterial-based Electrochemical Biosensorsmentioning

confidence: 99%

Advances in Nanomaterials-Based Electrochemical Biosensors for Foodborne Pathogen Detection

et al. 2021

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Electrochemical biosensors utilizing nanomaterials have received widespread attention in pathogen detection and monitoring. Here, the potential of different nanomaterials and electrochemical technologies is reviewed for the development of novel diagnostic devices for the detection of foodborne pathogens and their biomarkers. The overview covers basic electrochemical methods and means for electrode functionalization, utilization of nanomaterials that include quantum dots, gold, silver and magnetic nanoparticles, carbon nanomaterials (carbon and graphene quantum dots, carbon nanotubes, graphene and reduced graphene oxide, graphene nanoplatelets, laser-induced graphene), metal oxides (nanoparticles, 2D and 3D nanostructures) and other 2D nanomaterials. Moreover, the current and future landscape of synergic effects of nanocomposites combining different nanomaterials is provided to illustrate how the limitations of traditional technologies can be overcome to design rapid, ultrasensitive, specific and affordable biosensors.

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“…Graphene and GO play an important role in the medical and electronic fields due to their antibacterial properties and detection capabilities ( Yeet al., 2015 ). In the last several decades, two-dimensional materials have been the most widely used materials for the manufacture of biosensors due to their high affinity, cost-effectiveness and ease of use ( Nguyen et al., 2020 ). Studies have shown that GO and graphene have antibacterial and antiviral properties ( Akhavan et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Can the application of graphene oxide contribute to the fight against COVID-19? Antiviral activity, diagnosis and prevention

Rhazouani

Aziz

Gamrani

et al. 2021

Current Research in Pharmacology and Drug Discovery

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COVID-19 is an infectious disease that affects the respiratory system and is caused by the novel coronavirus SARS-CoV-2. It was first reported in Wuhan, China, on December 31, 2019, and has affected the entire world. This pandemic has caused serious health, economic and social problems. In this situation, the only solution to combat COVID-19 is to accelerate the development of antiviral drugs and vaccines to mitigate the virus and develop better antiviral methods and excellent diagnostic and prevention techniques. With the development of nanotechnology, nanoparticles are being introduced to control COVID-19. Graphene oxide (GO), an oxidized derivative of graphene, is currently used in the medical field to treat certain diseases such as cancer. It is characterized by very important antiviral properties that allow its use in treating certain infectious diseases. The GO antiviral mechanism is discussed by the virus inactivation and/or the host cell receptor or by the physicochemical destruction of viral species. Moreover, the very high surface/volume ratio of GO allows the fixation of biomolecules by simple absorption. This paper summarizes the different studies performed on GO's antiviral activities and discusses GO-based biosensors for virus detection and approaches for prevention.

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Recent advancement in biomedical applications on the surface of two-dimensional materials: from biosensing to tissue engineering

Abstract: This review highlights the importance of the dimensionality and surface interactions of 2D materials with examples of recent biosensing and biomedical applications.

Cited by 54 publications

References 222 publications

Nanodiagnostics to Face SARS-CoV-2 and Future Pandemics: From an Idea to the Market and Beyond

Nanodiagnostics to Face SARS-CoV-2 and Future Pandemics: From an Idea to the Market and Beyond

Advances in Nanomaterials-Based Electrochemical Biosensors for Foodborne Pathogen Detection

Can the application of graphene oxide contribute to the fight against COVID-19? Antiviral activity, diagnosis and prevention

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